Geminal bis(silane)-controlled regio- and stereoselective oxidative Heck reaction of enol ethers with terminal alkenes to give push-pull 1,3-dienes
Geminal bis(silane)-controlled regio- and stereoselective oxidative Heck reaction of enol ethers with terminal alkenes to give push-pull 1,3-dienes
复制标题
双（硅烷）控制的烯醇醚与末端烯烃的区域和立体选择性氧化 Heck 反应生成推拉 1,3-二烯
DOI：
10.1039/c5cc06448a
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Song, Zhenlei
中科院分区：
文献类型：
--
作者：
Li, Linjie;Chu, Yang;Song, Zhenlei
发展了双(硅烷)控制的烯醇醚与端烯的区域和立体选择性氧化Heck反应。该反应以α，β偶联的区域选择性进行，以良好的产率得到推拉式Z，E-1，3-二烯。该产物在樱花与缩醛的高烯丙基化反应中显示出良好的抗选择性，可用于合成α-取代-伽马酮酸酯。
A geminal bis(silane)-controlled regio- and stereoselective oxidative Heck reaction of enol ethers with terminal alkenes has been developed. The reaction proceeds with alpha,beta-coupling regioselectivity to give push-pull Z,E-1,3-dienes in good yields. The product showed valuable utility in Sakurai homoallylation with acetals to generate alpha-substituted-gamma-keto esters with good anti-selectivity.