Social management of LPS-induced inflammation in Formica polyctena ants
Social management of LPS-induced inflammation in Formica polyctena ants
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DOI：
10.1016/j.bbi.2008.01.010
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发表时间：
2008-08-01
影响因子：
15.1
通讯作者：
Richard, F. -J.
中科院分区：
文献类型：
--
作者：
Aubert, A.;Richard, F. -J.
无脊椎动物，特别是昆虫，是研究免疫相关行为进化根源的宝贵和方便的模型。蚂蚁等群居昆虫的巢穴环境稳定，种群密度高，相互作用频繁，为研究病原体的传播提供了一个很好的系统。这些物种的进化成功提出了关于社会昆虫对受感染的巢友的行为反应的问题。在本实验中，我们测试了红蚁对免疫刺激的巢友的行为变化。我们使用细菌内毒素（脂多糖，LPS）激活个体工蚁的先天免疫系统，而不会使我们的观察受到来自活病原体的可能线索或宿主操纵的影响。我们发现，LPS诱导的免疫激活蚂蚁触发行为的变化，在巢友。与预期的相反，我们没有发现去除策略（例如，竞争行为）或避免病原源，而是在病原体传播的限制（即，LPS处理的蚂蚁的减少的trophaltaxis和运动）与可能构成“社会疫苗接种”的行为基础（即，增加梳理）之间的平衡。这支持了社会互动在社会性昆虫（也许是一般的社会性动物）抵抗疾病中的重要性。(c)2008年爱思唯尔公司All rights reserved.
Invertebrates, and especially insects, constitute valuable and convenient models for the study of the evolutionary roots of immune-related behaviors. With stable conditions in the nest, high population densities, and frequent interactions, social insects such as ants provide an excellent system for examining the spread of pathogens. The evolutionary success of these species raises questions about the behavioral responses of social insects to an infected nestmate. In this experiment, we tested the behavioral changes of the red wood ant Formica polyctena toward an immune-stimulated nestmate. We used bacterial endotoxin (lipopolysaccharides, LPS) to active the innate immune system of individual worker ants without biasing our observation with possible cues or host-manipulation from a living pathogen. We show that LPS-induced immune activation in ants triggers behavioral changes in nestmates. Contrary to what would be expected, we did not find removal strategies (e.g. agonistic behaviors) or avoidance of the pathogenic source, but rather a balance between a limitation of pathogen dissemination (i.e. decreased trophallaxis and locomotion of the LPS-treated ant), and what could constitute the behavioral basis for a "social vaccination" (i.e. increased grooming). This supports the importance of social interactions in resistance to disease in social insects, and perhaps social animals in general. (c) 2008 Elsevier Inc. All rights reserved.