Effects of personality disorders on functioning and well-being in major depressive disorder.
Effects of personality disorders on functioning and well-being in major depressive disorder.
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DOI：
10.1097/00131746-200511000-00002
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发表时间：
2005-11-01
影响因子：
1.9
通讯作者：
McGlashan, Thomas H
中科院分区：
文献类型：
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作者：
Skodol, Andrew E;Grilo, Carlos M;McGlashan, Thomas H
背景技术背景：与慢性疾病患者相比，抑郁症患者的身体和情感功能受到限制。人格障碍（PD）也被认为与功能障碍有关。目的：确定PD对重度抑郁症（MDD）患者的功能和健康的影响。方法：在合作纵向人格障碍研究中，668名符合典型，边缘，回避，在基线、6、12、24和36个月时，采用半结构化访谈对强迫性PD或MDD和无PD患者进行评估。在本研究中，根据存在（n = 118）或不存在（n = 33）持续性PD，对36个月随访时符合当前MDD标准的151例患者进行了比较。使用医学结局研究（MOS）简表健康调查（SF-36）评估身体和社会/情感功能和幸福感。这些结果进行了比较，在精神卫生专业部门的MDD患者的样本中，谁是随后在医疗Outcomes Study.RESULTS：MDD患者和共同发生的PD有显着更多的损害尺度测量的角色限制，由于情绪问题，社会功能，和一般的健康观念比MDD患者，没有PD。虽然MDD和没有PD的患者被发现在几个领域的功能和幸福感水平低于以前在精神卫生机构招募的抑郁症患者中报道的水平，但MDD和共同发生的PD患者被发现在所有领域的功能水平都比报道的样本低得多。共发PD显著导致MDD患者的社会和情感功能受损以及幸福感降低。
BACKGROUND: Patients with depressive disorders have limitations in physical and emotional functioning comparable to patients with chronic medical conditions. Personality disorders (PDs) are also known to be associated with functional impairment.AIMS: To determine the effects of PDs on the functioning and well-being of patients with major depressive disorder (MDD).METHOD: In the Collaborative Longitudinal Personality Disorders Study, 668 patients who met criteria for schizotypal, borderline, avoidant, or obsessive-compulsive PDs or for MDD and no PD were assessed with semi-structured interviews at baseline, 6, 12, 24, and 36 months. In this study, 151 patients who met criteria for current MDD at the 36-month follow-up were compared on the basis of the presence (n = 118) or absence (n = 33) of persistent PD. Physical and social/emotional functioning and well-being were assessed using the Medical Outcomes Study (MOS) Short-Form Health Survey (SF-36). These results were compared with those of a sample of patients with MDD seen in the mental health specialty sector who were followed in the Medical Outcomes Study.RESULTS: Patients with MDD and co-occurring PD had significantly more impairment on scales measuring role limitations due to emotional problems, social functioning, and general health perceptions than patients with MDD and no PD. Although patients with MDD and no PD were found to have levels of functioning and well-being that were lower in several domains than those previously reported in depressed patients recruited from mental health settings, patients with MDD and co-occurring PD were found to have much lower levels of functioning in all areas than reported samples.CONCLUSIONS: Co-occurring PDs contribute significantly to impairment in social and emotional functioning and reduced well-being in patients with MDD.