EFFECTS OF HYPERTHYROIDISM AND HYPOTHYROIDISM ON GLUTAMINE-METABOLISM BY SKELETAL-MUSCLE OF THE RAT
EFFECTS OF HYPERTHYROIDISM AND HYPOTHYROIDISM ON GLUTAMINE-METABOLISM BY SKELETAL-MUSCLE OF THE RAT
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DOI：
10.1042/bj2720319
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发表时间：
1990-12-01
影响因子：
4.1
通讯作者：
NEWSHOLME, EA
中科院分区：
文献类型：
--
作者：
PARRYBILLINGS, M;DIMITRIADIS, GD;NEWSHOLME, EA
1.本文研究了甲状腺功能亢进和甲状腺功能减退对大鼠比目鱼肌和血浆中谷氨酰胺和其它氨基酸浓度的影响，以及对离体肌谷氨酰胺和丙氨酸释放速率的影响。2.甲亢可降低比目鱼肌中谷氨酰胺的含量，但对腓肠肌和血浆中谷氨酰胺含量无影响。甲状腺功能亢进也显着增加谷氨酰胺从孵育比目鱼肌的释放率。3.甲状腺功能减退使腓肠肌和血浆中谷氨酰胺含量降低，但对比目鱼肌中谷氨酰胺含量无影响。甲状腺功能减退也显着降低谷氨酰胺释放率从孵育比目鱼肌。4.甲状腺状态被发现有显着的影响，骨骼肌本身的谷氨酰胺释放的速度，并可能是重要的控制这一过程中的生理和病理条件。
1. The effects of hyperthyroidism and hypothyroidism on the concentrations of glutamine and other amino acids in the muscle and plasma and on the rates of glutamine and alanine release from incubated isolated stripped soleus muscle of the rat were investigated. 2. Hyperthyroidism decreased the concentration of glutamine in soleus muscle but was without effect on that in the gastrocnemius muscle or in the plasma. Hyperthyroidism also increased markedly the rate of release of glutamine from the incubated soleus muscle. 3. Hypothyroidism decreased the concentrations of glutamine in the gastrocnemius muscle and plasma but was without effect on that in soleus muscle. Hypothyroidism also decreased markedly the rate of glutamine release from the incubated soleus muscle. 4. Thyroid status was found to have marked effects on the rate of glutamine release by skeletal muscle per se, and may be important in the control of this process in both physiological and pathological conditions.