Gastric signet-ring adenocarcinoma presenting with breast metastasis
Gastric signet-ring adenocarcinoma presenting with breast metastasis
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DOI：
10.3748/wjg.v12.i18.2958
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发表时间：
2006-05-14
影响因子：
4.3
通讯作者：
Mouratidou, Despina
中科院分区：
文献类型：
--
作者：
Boutis, Anastasios L.;Andreadis, Charalambos;Mouratidou, Despina
胃癌的乳腺转移极为罕见。描述一例 37 岁女性乳腺炎性浸润并腹水的病例报告。乳腺活检显示具有印戒特征的腺癌细胞对淋巴管的癌性侵袭。雌激素 (ER) 和孕激素受体 (PR) 以及 c-erb-B2 均为阴性。上消化道内镜检查显示幽门前溃疡性肿块。病变的组织病理学检查显示高级别腺癌浸润，与乳房相同。细胞角蛋白 CK-7、CK-20 和 CEA 免疫染色呈阳性，ER 和 PR 呈阴性。腹水细胞学检查腺癌细胞阳性。乳房X光检查不能诊断。腹部 CT 扫描显示较大的卵巢肿块提示转移（克鲁肯伯格肿瘤）。给予了基于顺铂的治疗方案，但没有观察到客观反应。患者在初步诊断后六个月死亡。对文献进行了回顾。 (C) 2006 年 WJG 出版社。版权所有。
Breast metastases from gastric cancer are extremely rare. A case report of a 37-year-old female with breast inflammatory invasion and ascites is described. Breast biopsy revealed carcinomatous invasion of the lymphatics from adenocarcinoma cells with signet-ring features. Estrogen (ER) and progesterone receptors (PR) and c-erb-B2 were negative. Upper gastrointestinal endoscopy revealed a prepyloric ulcerative mass. Histopathologic examination of the lesion showed infiltration from a high-grade adenocarcinoma, identical with that of the breast. Immunostaining was positive for cytokeratins CK-7 and CK-20 and CEA and negative for ER and PR. Ascitic fluid cytology was positive for adenocarcinoma cells. Mammography was not diagnostic. Abdominal CT scanning revealed large ovarian masses suggestive of metastases (Krukenberg's tumor). A cisplatin-based regimen was given but no objective response was observed. The patient died six months after initial diagnosis. A review of the literature is performed. (C) 2006 The WJG Press. All rights reserved.