Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement
Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement
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DOI：
10.1089/thy.1999.9.435
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发表时间：
1999-05-01
期刊：
影响因子：
6.6
通讯作者：
Nicoloff, JT
中科院分区：
文献类型：
--
作者：
Spencer, CA;LoPresti, JS;Nicoloff, JT
甲状腺球蛋白（Tg）测定主要用于监测分化型甲状腺癌（DTC）患者的肿瘤复发。血清Tg水平主要结合3个变量：甲状腺组织的肿块（良性或肿瘤）；促甲状腺激素（TSH）受体的刺激程度和肿瘤合成和分泌Tg-a因子的内在能力需要通过术前血清Tg测定来评估。血清Tg测量值应与患者TSH状态相关。当TSH较低时（使用左旋甲状腺素[LT4]治疗），基础血清Tg可能无法检测到，可能需要重组人促甲状腺素（rhTSH）给药以将血清Tg增加到可测量的范围。Tg对rhTSH的折叠反应（rhTSH刺激Tg/基础Tg）是谣言对TSH敏感性的一个指标。正常甲状腺残余和分化良好的甲状腺肿瘤对TSH刺激的血清Tg反应比分化较差的肿瘤(
Thyroglobulin (Tg) measurement is primarily used to monitor patients with differentiated thyroid carcinoma (DTC) for tumor recurrence. Serum Tg levels principally integrate 3 variables: the mass of thyroid tissue present (benign or neoplastic); the degree of thyrotropin (TSH) receptor stimulation and tumor's intrinsic ability to synthesize and secrete Tg-a factor that needs to be assessed by a preoperative serum Tg determination. Serum Tg measurements should be interpreted relative to the TSH status of the patient. When TSH is low (on levothyroxine [LT4] therapy) basal serum Tg may be undetectable and recombinant human thyrotropin (rhTSH) administration may be needed to increase serum Tg into the measureable range. The Tg fold response to rhTSH (rhTSH-stimulated Tg/basal Tg) is an index of the rumor's sensitivity to TSH. Normal thyroid remnant and well-differentiated thyroid tumors display a greater (>10-fold) serum Tg response to TSH stimulation compared with less well-differentiated tumors (