Clinical utility of complement assessment

Clinical utility of complement assessment
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补体评估的临床效用

DOI:
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发表时间:
1995
期刊:
Clinical and Diagnostic Laboratory Immunology
影响因子:
--
通讯作者:
J. Peter
J. Peter
中科院分区:
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文献类型:
--
作者:
A. Ahmed;J. Peter

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通过其多种功能活动,补体系统在宿主防御感染和炎症过程中起主要作用。该系统由超过25种自组装蛋白组成,分为三组(经典途径,替代途径和末端序列;表1),以及一系列受体和调节蛋白。这些部件串联和并联作用以实现几个重要功能(52、84、86)。补体激活的顺序已在其他地方进行了广泛的综述(57,86),并在图1中进行了总结。
Via its multiple functional activities, the complement system plays a major role in host defense against infection and in inflammatory processes. The system consists of more than 25 self-assembling proteins divided into three groups (classical pathway, alternative pathway, and terminal sequence; Table 1), as well as a series of receptors and regulatory proteins. These components act in series and in parallel to achieve several important functions (52, 84, 86). The sequence of complement activation has been reviewed extensively elsewhere (57, 86) and is summarized in Fig. 1.
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