Spatial Representation of Odorant Valence in an Insect Brain
Spatial Representation of Odorant Valence in an Insect Brain
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DOI：
10.1016/j.celrep.2012.03.002
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发表时间：
2012-04-01
期刊：
影响因子：
8.8
通讯作者：
Hansson, Bill S.
中科院分区：
文献类型：
--
作者：
Knaden, Markus;Strutz, Antonia;Hansson, Bill S.
大脑必须根据复杂的感觉输入来决定是否以及如何对检测到的刺激做出反应。醋蝇黑腹果蝇根据嗅觉线索评估食物来源。在这里，我们使用醋蝇进行了行为筛选，并建立了110种气味的固有价。我们的分析引起的有吸引力的和厌恶的气味的神经元激活模式表明，即使气味的身份是由一组激活的受体编码，气味价的主要代表性形成在触角叶的输出水平。在触角叶的价特异性输出神经元的地形集群类似于在小鼠嗅球的相应域。昆虫和脊椎动物之间的嗅觉回路的基本解剖结构是相似的，我们的研究表明，气味化合价的表示也是如此。
Brains have to decide whether and how to respond to detected stimuli based on complex sensory input. The vinegar fly Drosophila melanogaster evaluates food sources based on olfactory cues. Here, we performed a behavioral screen using the vinegar fly and established the innate valence of 110 odorants. Our analysis of neuronal activation patterns evoked by attractive and aversive odorants suggests that even though the identity of odorants is coded by the set of activated receptors, the main representation of odorant valence is formed at the output level of the antennal lobe. The topographic clustering within the antennal lobe of valence-specific output neurons resembles a corresponding domain in the olfactory bulb of mice. The basal anatomical structure of the olfactory circuit between insects and vertebrates is known to be similar; our study suggests that the representation of odorant valence is as well.