Serum cholesterol reduction and cholesterol absorption inhibition in CaCo-2 cells by a soyprotein peptic hydrolyzate
Serum cholesterol reduction and cholesterol absorption inhibition in CaCo-2 cells by a soyprotein peptic hydrolyzate
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DOI：
10.1271/bbb.61.354
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发表时间：
1997-02-01
影响因子：
1.6
通讯作者：
Hashimoto, K
中科院分区：
文献类型：
--
作者：
Nagaoka, S;Awano, T;Hashimoto, K
与酪蛋白胰蛋白酶水解物（CTH）组相比，大豆蛋白消化酶水解物（SPH）组大鼠血清胆固醇水平显著降低。与CTH饮食相比，SPH饮食喂养的大鼠粪便中总类固醇排泄量显著增加。CaCo-2研究的结果清楚地表明，抑制肠上皮细胞中的胆固醇吸收是SPH诱导的降胆固醇作用的机制的一部分。
The serum cholesterol level in rats was significantly decreased in a group fed on a soyprotein peptic hydrolyzate (SPH) when compared,vith a group fed on a casein tryptic hydrolyzate (CTH). The fecal excretion of total steroids was significantly greater with rats fed on the SPH diet when compared with the CTH diet. The results of CaCo-2 studies clearly suggest that the suppression of cholesterol absorption in the intestinal epithelia is part of the mechanism for the hypocholesterolemic action induced by SPH.