Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma:: a 5 year randomized trial
Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma:: a 5 year randomized trial
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DOI：
10.1684/ejd.2008.0472
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发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Wolf, Peter
中科院分区：
文献类型：
--
作者：
Basset-Seguin, Nicole;Ibbotson, Sally H.;Wolf, Peter
这项多中心、随机研究比较了使用局部氨基乙酰丙酸甲酯（MAL PDT）的光动力疗法（一种非侵入性方式）与冷冻疗法治疗浅表基底细胞癌。60例患者的114个病灶在照射（570-670 nm，光剂量75 J/cm）（I期）前用MAL乳膏（160 mg/g）治疗3小时，58例患者的105个病灶接受冷冻治疗（2个冻融循环）。3个月时反应不完全的患者接受2次MAL PDT治疗（n = 20）或重复冷冻治疗（n = 16）。100个用MAL PDT治疗的病灶和93个用冷冻治疗的病灶在最后一次治疗后3个月完全缓解，并且可评估5年内的复发。两种治疗的5年复发率无差异（冷冻治疗为20%，MAL PDT为22%，p = 0.86）。然而，MAL PDT组有更多患者的美容效果极佳（60% vs.冷冻治疗组16%，p = 0.00078）。这些结果为MAL PDT作为原发性浅表基底细胞癌的非侵入性、选择性治疗选择提供了支持。
This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.