Influence of endogenous opiates on anterior pituitary function.
Influence of endogenous opiates on anterior pituitary function.
复制标题
内源性阿片类药物对垂体前叶功能的影响。
DOI：
--
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Joseph Meites
中科院分区：
文献类型：
--
作者：
D. A. V. Vugt;Joseph Meites
一般来说，内源性阿片肽（EOP）、吗啡（莫尔）和相关药物对垂体激素的急性释放具有相似的作用。因此，阿片类药物的给药导致催乳素（PRL）、生长激素（GH）、促肾上腺皮质激素（ACTH）和抗利尿激素（ADH）的释放迅速增加，而促性腺激素和促甲状腺激素（TSH）的释放减少。虽然尚未完全确定，但越来越多的证据表明EOP参与垂体激素分泌的生理调节。纳洛酮（NAL）是一种特异性阿片受体拮抗剂，可降低雄性大鼠基础血清PRL和GH水平，升高血清LH和卵泡刺激素水平。其他报告表明，NAL可以抑制应激诱导的血清PRL升高，使去势诱导的血清LH升高至高于正常去势值，并抵消雌激素和睾酮对LH分泌的抑制作用。阿片类药物似乎对脑垂体没有直接作用，但有证据表明，它们可以改变下丘脑多巴胺和5-羟色胺的活性，从而调节脑垂体激素的分泌。
In general, the endogenous opioid peptides (EOP), morphine (MOR), and related drugs exert similar effects on acute release of pituitary hormones. Thus administration of opiates produces a rapid increase in release of prolactin (PRL), growth hormone (GH), adrenocorticotropin (ACTH), and antidiuretic hormone (ADH), and a decrease in release of gonadotropins and thyrotropin (TSH). Although not yet fully established, there is growing evidence that the EOP participate in the physiological regulation of pituitary hormone secretion. Thus naloxone (NAL), a specific opiate antagonist, has been shown to reduce basal serum levels of PRL and GH, and to elevate serum levels of LH and follicle stimulating hormone in male rats. Other reports have shown that NAL can inhibit the stress-induced rise in serum PRL, raise the castration-induced increase in serum LH to greater than normal castrate values, and counteract the inhibitory effects of estrogen and testosterone on LH secretion. Opiates appear to have no direct action on the pituitary, but there is evidence that they can alter activity of hypothalamic dopamine and serotonin in modulating secretion of pituitary hormones.