Know your target, know your molecule
Know your target, know your molecule
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DOI：
10.1038/nchembio.1813
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发表时间：
2015-06-01
影响因子：
14.8
通讯作者：
Hett, Erik C.
中科院分区：
文献类型：
--
作者：
Bunnage, Mark E.;Gilbert, Adam M.;Hett, Erik C.
在二期概念验证临床研究期间，制药行业继续经历候选药物的显著流失。我们描述了一些关于蛋白质靶点和小分子药物特征的问题，这些问题可能是药物发现项目中重要的考虑因素，并可能改善未来临床成功的前景。
The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some questions about the characteristics of protein targets and small-molecule drugs that may be important to consider in drug-discovery projects and could improve prospects for future clinical success.