Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study.
Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study.
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母亲血清全氟烷基物质浓度与青春期早期骨矿含量和密度的关系：健康结果和环境措施研究(HOME)。
DOI：
10.1289/ehp9424
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发表时间：
2021-09
影响因子：
10.4
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Buckley JP;Kuiper JR;Lanphear BP;Calafat AM;Cecil KM;Chen A;Xu Y;Yolton K;Kalkwarf HJ;Braun JM
全氟烷基和多氟烷基物质（PFAS）可能通过内分泌干扰和核受体激动作用损害骨生成和强度，但人体研究主要是成人或横断面研究。我们评估了怀孕期间PFAS个体及其混合物与12岁儿童骨矿物质含量（BMC）和面骨矿物质密度（aBMD）的关系。在2003-2006年的前瞻性队列研究中，我们对206对母婴进行了全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟己烷磺酸（PFHxS）和全氟辛烷磺酸（PFOS）的定量分析。当儿童年龄为12岁时，我们进行双能X线骨密度测定，并计算6个骨骼部位的BMC、aBMD和骨矿物质表观密度（BMAD）评分。我们估计协变量调整后的得分差异，每加倍的个人PFAS使用线性回归和评估PFAS混合使用分位数g计算和贝叶斯核机器回归。我们探讨了儿童的性别或介导的全身瘦体重是否修改协会。在协变量调整模型中，我们发现母亲血清中PFOA、PFNA和PFAS混合物浓度较高与儿童全髋关节和前臂（桡骨远端三分之一）BMC评分较低相关。PFOA和PFNA每增加一倍，前臂BMC评分的差异分别为[95%置信区间（CI）：，0.01]和（95% CI：，），PFAS混合物每增加四分位数（95% CI：，）。儿童的性别改变了某些骨骼部位的PFOA相关性;例如，男性和女性的脊柱BMAD -每加倍评分差异分别为（95% CI：，）和0.07（95% CI：，0.30）（改变）。除了女性中的PFNA，这些协会没有介导的全身瘦体重。妊娠期母体PFAS浓度可能与青春期早期骨矿物质积累和强度降低相关。https://doi.org/10.1289/EHP9424
Per- and polyfluoroalkyl substances (PFAS) may impair bone accrual and strength via endocrine disruption and nuclear receptor agonism, but human studies are primarily of adults or cross-sectional. We assessed associations of individual PFAS and their mixture during pregnancy with child bone mineral content (BMC) and areal bone mineral density (aBMD) at age 12 y. Among 206 mother–child pairs enrolled in a prospective cohort (2003–2006), we quantified perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in maternal serum collected during gestation or delivery. When children were age 12 y, we performed dual energy X-ray absorptiometry and calculated BMC, aBMD, and bone mineral apparent density (BMAD) -scores for six skeletal sites. We estimated covariate-adjusted -score differences per doubling of individual PFAS using linear regression and assessed the PFAS mixture using quantile g-computation and Bayesian kernel machine regression. We explored whether associations were modified by child’s sex or mediated by whole-body lean mass. In covariate-adjusted models, we found that higher maternal serum concentrations of PFOA, PFNA, and the PFAS mixture were associated with lower total hip and forearm (one-third distal radius) BMC -scores in children. Differences in forearm BMC -scores were [95% confidence interval (CI): , 0.01] and (95% CI: , ) per doubling of PFOA and PFNA, respectively, and (95% CI: , ) per quartile increase in the PFAS mixture. Child’s sex modified PFOA associations for some skeletal sites; for example, differences in spine BMAD -score per doubling were (95% CI: , ) among males and 0.07 (95% CI: , 0.30) among females (modification ). Except for PFNA among females, these associations were not mediated by whole-body lean mass. Maternal PFAS concentrations during pregnancy may be associated with lower bone mineral accrual and strength in early adolescence. https://doi.org/10.1289/EHP9424