Impact of known risk factors on endometrial cancer burden in Chinese women.
Impact of known risk factors on endometrial cancer burden in Chinese women.
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DOI：
10.1097/cej.0000000000000178
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Xiang YB
中科院分区：
文献类型：
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作者：
Gao J;Yang G;Wen W;Cai QY;Zheng W;Shu XO;Xiang YB
本研究旨在提供已知危险因素对子宫内膜癌负担影响的数据。对1997 ~ 2003年上海市1199例子宫内膜癌患者和1212例正常对照者的病例对照研究资料进行多因素非条件Logistic回归分析。计算部分人群归因风险，并使用bootstrap方法估计相应的95%置信区间（95%CI）。据估计，16.94%的子宫内膜癌病例归因于超重或肥胖; 8.39%归因于肉类摄入; 5.45%归因于不定期喝茶; 5.23%归因于缺乏运动; 1.77%归因于子宫内膜癌、乳腺癌或结直肠癌的家族史。这些危险因素占子宫内膜癌病例总数的36.01%（95%CI：28.55%~ 43.11%）。当分析仅限于绝经后妇女时，观察到类似的结果。在可改变的生活方式因素中，超重和肥胖占研究人群中子宫内膜癌的最大比例。生活方式的改变，如保持健康的体重，经常锻炼，少吃肉，喝茶，可以预防子宫内膜癌超过三分之一。
This study aimed to provide data on the impact of known risk factors on endometrial cancer burden. Using data of 1 199 endometrial cancer cases and 1 212 frequency matched controls from a population-based case-control study carried out in urban Shanghai, China from 1997 to 2003, multivariable adjusted odds ratios were obtained from unconditional logistic regression analyses. Partial population attributable risks were calculated and corresponding 95% confidence intervals (95% CIs) were estimated using a bootstrap method. An estimated 16.94% of endometrial cancer cases were attributed to overweight or obesity; 8.39% to meat intake; 5.45% to non-regular tea drinking; 5.23% to physical inactivity; and 1.77% to family history of endometrial, breast, or colorectal cancers. Overall, these risk factors accounted for 36.01% (95%CI: 28.55%-43.11%) of total endometrial cancer cases. Similar results were observed when analysis was restricted to post-menopausal women. Among modifiable lifestyle factors, overweight and obesity accounted for the largest proportion of endometrial cancer in the study population. Lifestyle alterations, such as maintenance of healthy weight, regular exercise, consumption of less meat, and tea drinking, could potentially prevent endometrial cancer by more than one third.