A Noninvasive Multimodal Sono-contrast NIR Spectroscopy System for Breast Cancer Diagnosis
A Noninvasive Multimodal Sono-contrast NIR Spectroscopy System for Breast Cancer Diagnosis
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用于乳腺癌诊断的无创多模式声对比近红外光谱系统
DOI：
10.1109/bibe.2010.55
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
L. Liao
中科院分区：
文献类型：
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作者：
K. Yan;T. Podder;Ke Huang;Yan Yu;L. Liao
我们开发了一种结合光学光谱、超声和声辐射力(ARF)三种模式的多模式成像系统，以基于无创血管询问来提高乳腺癌的诊断水平。本文给出了详细的系统设计。本文还讨论了激光和超声波的使用安全问题。激光对皮肤的最大曝光量控制在0.2W·cm-2(ANSI Z136.1)内；ARF野的曝光量保持在FDA诊断限值(0.72W·cm-2)以下。这种多模式系统具有改善肿瘤检测的潜力，通过部署ARF来产生组织血液供应环境的动态行为的可测量差异，如光学光谱所询问的，这在小鼠肿瘤模型中被证明是高度诊断的。正在进行试点临床研究。
We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W•cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W•cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.