Negative and independent influence of apolipoprotein E on C-reactive protein (CRP) concentration in obese adults. Potential anti-inflammatory role of apoE in vivo
Negative and independent influence of apolipoprotein E on C-reactive protein (CRP) concentration in obese adults. Potential anti-inflammatory role of apoE in vivo
复制标题
载脂蛋白 E 对肥胖成人 C 反应蛋白 (CRP) 浓度的负面独立影响。
DOI：
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发表时间：
2001
影响因子：
4.9
通讯作者：
Jean
中科院分区：
文献类型：
--
作者：
Kalyane Bach;Hassan Nazih;F. Nazih;Y. Zair;D. L. Carrer;Michel Krempf;Jean
背景技术背景：肥胖通常与早期炎症标志物C反应蛋白（CRP）、胰岛素抵抗和脂蛋白代谢变化的增加有关。CRP升高被认为是一个独立的心血管危险因素。由于HDL的载脂蛋白（apo）E和CIII组分与降低的心血管风险相关，并且由于apoE具有体外抗炎作用，我们研究了肥胖成年人中apoE、apoCIII（在含apoB和不含apoB的脂蛋白中）和CRP之间的关系 。（1）ApoE和apoCIII，总血浆中，含apoB的脂蛋白（E LpB，CIII LpB）和不含apoB的脂蛋白（E LpnonB，CIII LpnonB）;（2）CRP和脂肪组织分泌的细胞因子（TNF-α及其可溶性受体TNFR 2）;（3）甘油三酯、HDL-胆固醇、收缩压、舒张压、腰围和臀围、胰岛素、葡萄糖。结果：CRP与BMI（P<0.05）、腰围（P<0.05）、甘油三酯（P <0.05）呈正相关，与apoE（P<0.01）、E LpnonB（P <0.05）呈负相关。逐步运行两个多元回归模型，包括P<0.25的与CRP相关的参数，以评估其对CRP浓度的独立贡献。在第一个模型（包括BMI、WC、HOMA、胰岛素、甘油三酯、apoE、E LpnonB）中，apoE与甘油三酯（P = 0.02）和BMI（P =0.08）是CRP的最佳预测因子（P = 0.01）。第二个模型考虑了E/CIII LpnonB比值，参数包括在第一个模型中。在第二个模型中，E/CIII LpnonB是CRP的最佳预测因子（P=0.007），解释了39%的CRP variation.CONCLUSION：ApoE与CRP密切相关，并可能在肥胖受试者体内具有抗炎作用。这种相关性可能仅限于LpnonB脂蛋白，这取决于它们的apoE和CIII相对含量。
BACKGROUND: Obesity is frequently associated with an increase in the early inflammation marker C-reactive protein (CRP), insulin resistance and changes in lipoprotein metabolism. Increased CRP is known as an independent cardiovascular risk factor. Since the apolipoproteins (apo) E and CIII components of HDL are associated with reduced cardiovascular risk and since apoE has in vitro anti-inflammatory effect, we have investigated the relationships between apoE, apoCIII (in apoB and non apoB containing lipoproteins) and CRP in obese adults.METHODS: The following parameters from 34 healthy obese fasting women (age 22–64 y, body mass index (BMI) 28–68 kg/m2) were measured: (1) ApoE and apoCIII, in total plasma, in apoB- (E LpB, CIII LpB) and non-apoB-containing lipoproteins (E LpnonB, CIII LpnonB); (2) CRP and cytokine secreted by adipose tissue (TNF-α and its soluble receptor TNFR2); (3) triglyceride, HDL-cholesterol, systolic blood pressure, diastolic blood pressure, waist and hip circumferences, insulin, glucose. HOMA, a marker of insulin sensitivity, and the ratio E/CIII in LpB and LpnonB were calculated.RESULTS: CRP was positively correlated with BMI (P<0.05), waist circumference (WC, P<0.05), triglyceride (P<0.05) and negatively correlated with apoE (P<0.01) and E LpnonB (P<0.05). Two multiple regression models including parameters related to CRP with a P<0.25 were run stepwise to assess their independent contribution to CRP concentration. In the first model (including BMI, WC, HOMA, insulin, triglyceride, apoE, E LpnonB), apoE was the best predictor of CRP (P=0.01) together with triglyceride (P=0.02) and BMI (P=0.08). The second model took into account E/CIII LpnonB ratio with the parameters included in the first model. In this second model, E/CIII LpnonB was the best predictor of CRP (P=0.007), explaining 39% of CRP variance.CONCLUSION: ApoE is strongly correlated with CRP and could have an anti-inflammatory effect in vivo in obese subjects. This correlation could be limited to LpnonB lipoproteins, depending on their apoE and CIII relative content.
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影响因子：
6.5
作者：
A. Hasty;M. Linton;L. Swift;S. Fazio
通讯作者：
A. Hasty;M. Linton;L. Swift;S. Fazio
阿拉斯加原住民的载脂蛋白 E 和动脉粥样硬化。
影响因子：
5.3
作者：
Scheer,WD;Boudreau,DA;Malcom,GT;Middaugh,JP
通讯作者：
Middaugh,JP
影响因子：
37.8
作者：
BLANKENHORN, DH;ALAUPOVIC, P;AZEN, SP
通讯作者：
AZEN, SP
DOI：
10.1073/pnas.89.10.4471
发表时间：
1992-05-15
影响因子：
11.1
作者：
PIEDRAHITA, JA;ZHANG, SH;MAEDA, N
通讯作者：
MAEDA, N
人类载脂蛋白 E 代谢动态。
影响因子：
6.5
作者：
Blum,CB
通讯作者：
Blum,CB