Toll-like, receptor 8-mediated reversal of CD4+ regulatory T cell function
Toll-like, receptor 8-mediated reversal of CD4+ regulatory T cell function
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DOI：
10.1126/science.1113401
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发表时间：
2005-08-26
期刊：
影响因子：
56.9
通讯作者：
Wang, RF
中科院分区：
文献类型：
--
作者：
Peng, GY;Guo, Z;Wang, RF
CD4（+）调节性T （Treg）细胞具有抑制宿主免疫反应的深刻能力，但对这些细胞如何被调节知之甚少。我们描述了toll样受体（TLR） 8信号传导与Treg细胞功能控制的机制，其中人类TLR8的合成和天然配体可以逆转Treg细胞功能。这种作用与树突状细胞无关，但需要Treg细胞中TLR8-MYD88-IRAK4信号通路的功能。TLR8配体刺激的Treg细胞过继转移到荷瘤小鼠体内可增强抗肿瘤免疫。这些结果表明，TLR8信号可能在控制癌症和其他疾病的免疫反应中发挥关键作用。
CD4(+) regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism [inking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MYD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.