Enantiospecific toxicity, distribution and bioaccumulation of chiral antidepressant venlafaxine and its metabolite in loach (Misgurnus anguillicaudatus) co-exposed to microplastic and the drugs
Enantiospecific toxicity, distribution and bioaccumulation of chiral antidepressant venlafaxine and its metabolite in loach (Misgurnus anguillicaudatus) co-exposed to microplastic and the drugs
复制标题
手性抗抑郁药文拉法辛及其代谢物在微塑料和药物共暴露的泥鳅（Misgurnus anguillicaudatus）中的对映特异性毒性、分布和生物蓄积
DOI：
10.1016/j.jhazmat.2018.04.041
复制
发表时间：
2019-05-15
影响因子：
13.6
通讯作者：
Yu, Gang
中科院分区：
文献类型：
--
作者：
Qu, Han;Ma, Ruixue;Yu, Gang
本研究通过40天的共暴露，研究了手性抗抑郁药文拉法辛及其代谢物o-去甲基文拉法辛在鳗鲡（m.a anguillicaudatus）体内的对端选择性行为，以及微塑料对其毒性、分布和代谢的影响。文拉法辛和o -去甲基文拉法辛使泥鳅肝脏中SOD和MDA含量升高。此外，与微塑料共暴露可能会对泥鳅产生更大的不利影响。文拉法辛和o -去甲基文拉法辛在肝组织和肝亚细胞中均有分布。微塑料处理后，文拉法辛和o -去甲基文拉法辛在水中的浓度较低。同时，更多的污染物通过“载体”（微塑料）在肝脏中积累。文拉法辛和o -去甲基文拉法辛发生对映选择性行为，r -对映异构体被优先降解。微塑料存在时，文拉法辛和o -去甲基文拉法辛在肺泡组织中的生物蓄积因子（BAF）扩增10倍以上。在肝脏亚细胞结构中，微塑料可能有助于将更多的化合物输送到细微的区域，并延缓污染物在生物体中的代谢。本研究首次揭示了手性药物与微塑料复合污染的潜在生态效应和环境行为，可为同时存在的有机污染物与微塑料的环境风险评价提供重要信息。
In present study, we investigated the enantioselective behaviors of the chiral antidepressant venlafaxine and its metabolite O-desmethylvenlafaxine in loath Misgurnus anguillicaudatus (M. anguillicaudatus), as well as effects of microplastic on toxicity, distribution and metabolism through a 40-day co-exposure. The contents of SOD and MDA in loach liver elevated when the loach was exposed to venlafaxine and O-desmethylvenlafaxine. Moreover, co-exposure with microplastic might lead to more adverse effect against loach. The distribution of venlafaxine and O-desmethylvenlafaxine were both detected in loath tissues and liver subcellular. The concentrations of venlafaxine and O-desmethylvenlafaxine were lower in water in microplastic-present treatment. Whilst, more contaminants were accumulated in liver through the "vehicle" (microplastic). Enantioselective behavior of venlafaxine and O-desmethylvenlafaxine occurred with R-enantiomers being preferentially degraded. With microplastic present, the bioaccumulation factor (BAF) of venlafaxine and O-desmethylvenlafaxine in loath tissue amplified more than 10 times. In liver subcellular structure, microplastic may help to transport more compounds into subtle areas and postpone the contaminants metabolism in organisms. The present study for the first time gained an insight into the potential ecological effects and environmental behaviors of combined pollutions of chiral pharmaceuticals and microplastic, which could supply important information for environment risk assessment of concurrent organic pollutants and microplastic.