Clinical implications of delayed orthostatic hypotension A 10-year follow-up study
Clinical implications of delayed orthostatic hypotension A 10-year follow-up study
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DOI：
10.1212/wnl.0000000000002030
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发表时间：
2015-10-20
期刊：
影响因子：
9.9
通讯作者：
Freeman, Roy
中科院分区：
文献类型：
--
作者：
Gibbons, Christopher H.;Freeman, Roy
目的：探讨迟发性直立性低血压（OH）的远期预后。假设：迟发性OH是一种早期和较轻形式的OH，随着时间的推移而发展。方法：我们回顾了从2002年1月1日至2003年12月31日在我们中心完成自主神经测试的230例患者的病历。所有可获得的关于临床诊断、死亡率、药物使用和自主神经测试的信息被提取并纳入报告的结果。使用标准标准定义OH和延迟OH。结果：48例迟发性OH患者、42例OH患者和75例对照者有完整的随访数据。54%的延迟OH患者进展为OH。31%的迟发性OH患者发展为-突触核蛋白病。迟发性OH患者的10年死亡率为29%，基线OH患者的10年死亡率为64%，对照组为9%。发展为OH的患者10年死亡率为50%。进展为OH与发生-突触核蛋白病、基线糖尿病和基线自主神经测试结果异常有关。结论：迟发性OH经常发展为OH，并伴有高死亡率。
Objective:To define the long-term outcome of delayed orthostatic hypotension (OH).Hypothesis:Delayed OH is an early and milder form of OH that progresses over time.Methods:We reviewed the medical records of 230 previously reported patients who completed autonomic testing at our center from January 1, 2002, through December 31, 2003. All available information on clinical diagnosis, mortality, medication use, and autonomic testing were extracted and included in the reported outcomes. Standard criteria were used to define OH and delayed OH.Results:Forty-eight individuals with delayed OH, 42 individuals with OH, and 75 controls had complete follow-up data. Fifty-four percent of individuals with delayed OH progressed to OH. Thirty-one percent of individuals with delayed OH developed an -synucleinopathy. The 10-year mortality rate in individuals with delayed OH was 29%, in individuals with baseline OH was 64%, and in controls was 9%. The 10-year mortality of individuals who progressed to OH was 50%. Progression to OH was associated with developing an -synucleinopathy, baseline diabetes, and abnormal baseline autonomic test results.Conclusion:Delayed OH frequently progresses to OH with a high associated mortality.