Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods
Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods
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DOI：
10.1016/s0142-9612(03)00171-6
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发表时间：
2003-08-01
期刊：
影响因子：
14
通讯作者：
Zhang, MQ
中科院分区：
文献类型：
--
作者：
Ramay, HR;Zhang, MQ
本文介绍了一种将凝胶浇铸法与聚合物海绵法相结合制备大孔羟基磷灰石支架的新技术。这可以更好地控制支架的微观结构，提高支架的力学性能。通过这种技术，我们能够生产出具有聚合物海绵或凝胶铸造方法无法达到的机械和结构性能的支架。所制备的支架具有开放、均匀、相互连接的多孔结构，孔径为200-400 μ m。获得了与松质骨相似的5mpa的抗压屈服强度和与皮质骨相似的8gpa的抗压模量。利用扫描电镜对支架的孔隙形态、大小和分布进行了表征。利用x射线衍射和傅里叶变换红外光谱分别测定支架的晶体结构和化学成分。具有所需孔隙度、孔径的支架。并且可以通过使用适当结构的聚合物海绵来制备几何形状。2003爱思唯尔科学有限公司版权所有。
A new technique of combining the gel-casting and polymer sponge methods is introduced in this study to prepare macroporous hydroxyapatite scaffolds. which provides a better control over the microstructures of scaffolds and enhances their mechanical properties. With this technique, we were able to produce scaffolds with mechanical and structural properties that cannot be attained by either the polymer sponge or gel-casting method. The scaffolds prepared have an open, uniform and interconnected porous structure with a pore size of 200-400 mum. A compressive yield strength of similar to5MPa equivalent to that of cancellous bone and a compressive modulus of similar to 8 GPa similar to that of cortical bone were achieved. The pore morphology, size, and distribution of the scaffolds were characterized using a scanning electron microscope. X-ray diffraction and Fourier transform infrared spectroscopy were used to determine the crystal structure and chemical composition of scaffolds, respectively. Scaffolds with desired porosity, pore size. and geometry can be prepared by using polymer sponges of appropriate structures. (C) 2003 Elsevier Science Ltd. All rights reserved.