Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients
Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients
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DOI：
10.1002/hed.26279
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发表时间：
2020-05-21
影响因子：
2.9
通讯作者：
Saussez, Sven
中科院分区：
文献类型：
--
作者：
Lechien, Jerome R.;Cabaraux, Pierre;Saussez, Sven
目的通过患者自报结局问卷和客观心理物理测试，了解2019年轻型冠状病毒病（COVID-19）患者的嗅觉功能障碍（OD）情况。收集流行病学和临床资料。鼻投诉与鼻窦结果进行了评价-22。主观嗅觉和味觉状态与国家健康和营养检查调查进行了评估。目的OD采用心理物理测试进行评估。最常见的症状为乏力（72.9%）、头痛（60.0%）、鼻塞（58.6%）和鼻后滴漏（48.6%）。61.4%的患者自我报告嗅觉完全丧失。客观嗅觉检查确定嗅觉缺失41例（47.7%），嗅觉减退12例（14.0%），嗅觉正常33例（38.3%）。客观检测结果与主观报告的鼻塞或鼻后滴漏之间无相关性。结论在报告OD的COVID-19患者中，有相当比例的患者在客观检测中没有OD。
Objective To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID-19) through patient-reported outcome questionnaires and objective psychophysical testing.Methods COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests.Results Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip.Conclusion A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.