The neurobiology of pathological gambling and drug addiction: an overview and new findings
The neurobiology of pathological gambling and drug addiction: an overview and new findings
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DOI：
10.1098/rstb.2008.0100
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发表时间：
2008-10-12
影响因子：
6.3
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Potenza, Marc N.
赌博是一种流行的娱乐行为。据估计，大约5%的成年人有赌博问题。最严重的赌博形式，病态赌博（PG），被认为是一种心理健康状况。两个交替的非相互排斥的概念化的PG认为它是一种强迫性谱系障碍和“行为”成瘾。最适当的概念化的PG具有重要的理论和实践意义。数据表明PG和物质使用障碍之间的关系比PG和强迫症之间的关系更密切。本文将回顾PG的神经生物学数据，考虑其概念化的行为成瘾，讨论冲动作为一个基本的结构，并提出新的脑成像研究结果，研究神经相关的渴望状态PG相比，可卡因依赖。将讨论预防和治疗策略的影响。
Gambling is a prevalent recreational behaviour. Approximately 5% of adults have been estimated to experience problems with gambling. The most severe form of gambling, pathological gambling (PG), is recognized as a mental health condition. Two alternate non-mutually exclusive conceptualizations of PG have considered it as an obsessive-compulsive spectrum disorder and a 'behavioural' addiction. The most appropriate conceptualization of PG has important theoretical and practical implications. Data suggest a closer relationship between PG and substance use disorders than exists between PG and obsessive-compulsive disorder. This paper will review data on the neurobiology of PG, consider its conceptualization as a behavioural addiction, discuss impulsivity as an underlying construct, and present new brain imaging findings investigating the neural correlates of craving states in PG as compared to those in cocaine dependence. Implications for prevention and treatment strategies will be discussed.