Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk of Helicobacter pylori infection in the US.
Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk of Helicobacter pylori infection in the US.
复制标题
胃肠道症状和诊断与幽门螺杆菌感染的风险相关的种族/种族差异。
DOI：
10.2147/ceg.s144967
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发表时间：
2018
影响因子：
2.4
通讯作者：
Allsworth JE
中科院分区：
文献类型：
--
作者：
Huerta-Franco MR;Banderas JW;Allsworth JE
在美国，尚未在不同人种/种族群体中检查与幽门螺杆菌（HP）相关的患病率或胃肠道（GI）诊断/症状。使用Cerner Health Facts®数据库确定与GI诊断/症状相关的HP感染的种族/民族差异。这项横断面研究收集了2000-2015年期间来自以下种族/人种组的数据：8，236，317名白色、2，085，389名黑人、426，622名西班牙裔、293，156名亚太裔/岛民（API）和89，179名21-65岁的美洲原住民/阿拉斯加原住民（NA/AN）患者;然后分析了数据。主要因变量是HP的诊断（ICD-9-临床修改/ICD-10分类）。采用SAS 9.4版进行统计分析。对11，130，663例有胃肠道症状的患者进行了统计分析，其中152，086例患者感染呈阳性。西班牙裔和NA/AN患者中与上消化道症状/诊断相关的HP患病率最高。然而，黑人和API呈现与消化不良相关的HP的最高相对风险（RR（RR [95% CI] =11.2 [10.7-11.9]和14.2 [12.8-15.6]），消化性溃疡（RR =13.8 [13.3-14.5]和10.7 [9.3-12.3]）和萎缩性胃炎（RR =9 [8.5-9.6]和7.4 [6.4-8.5]）。在所有种族/民族组中，HP还与炎症性肠病、肝病和乳糜泻相关。黑人和API人群与上消化道症状/诊断相关的HP风险最高。黑人患者也有最高的风险与胃肠道癌相关的HP。
In the US, neither the prevalence nor the gastrointestinal (GI) diagnosis/symptoms associated with Helicobacter pylori (HP) have been examined in different racial/ethnic groups. To determine the racial/ethnic differences in HP infection associated with GI diagnoses/symptoms using the Cerner Health Facts® database. This cross-sectional study collected data during the period of 2000–2015 from the following ethnic/racial groups: 8,236,317 white, 2,085,389 black, 426,622 Hispanic, 293,156 Asian Pacific/Islander (APIs), and 89,179 Native American/Alaskan Native (NA/AN) patients aged 21–65 years old; the data were then analyzed. The primary dependent variable was a diagnosis of HP (ICD-9-Clinical Modification/ICD-10 classification). SAS version 9.4 was used for the statistical analysis. The statistical analysis was performed on 11,130,663 patients with GI symptoms, and of these, 152,086 patients were positive for the infection. Hispanics and NA/ANs had the highest prevalence of HP associated with upper GI symptoms/diagnosis. Nevertheless, blacks and APIs presented the highest relative risk (RR) of HP associated with dyspepsia (RR [95% CI] =11.2 [10.7–11.9] and 14.2 [12.8–15.6]), peptic ulcer (RR =13.8 [13.3–14.5] and 10.7 [9.3–12.3]), and atrophic gastritis (RR =9 [8.5–9.6] and 7.4 [6.4–8.5]), respectively. In all racial/ethnic groups, HP was also associated with inflammatory bowel diseases, liver diseases, and celiac diseases. Black and API populations had the highest risk of HP associated with upper GI symptoms/diagnosis. Black patients also had the highest risk for HP associated with GI cancer.