Double-Walled Au Nanocage/SiO2 Nanorattles: Integrating SERS Imaging, Drug Delivery and Photothermal Therapy
Double-Walled Au Nanocage/SiO2 Nanorattles: Integrating SERS Imaging, Drug Delivery and Photothermal Therapy
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DOI：
10.1002/smll.201401360
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发表时间：
2015-02-25
期刊：
影响因子：
13.3
通讯作者：
Wang, Qiangbin
中科院分区：
文献类型：
--
作者：
Hu, Feng;Zhang, Yan;Wang, Qiangbin
在这项工作中，通过结合两种“空心挖掘策略”——电偶置换和“表面保护蚀刻”，成功制备了一种新型纳米医学平台——双壁Au纳米笼/SiO2纳米拨片。基于金纳米笼（AuNC）和分别用对氨基苯硫酚（pATP）和Tat肽功能化的中空SiO2壳的双壁纳米结构的合理设计，同时使纳米平台具有三种功能：1）由于AuNC和SiO2壳具有中空内部的结构特征，整个纳米摇篮可作为高效药物载体 和多孔壁； 2）具有大电磁增强作用的AuNC可作为敏感的表面增强拉曼散射（SERS）基底来跟踪人类MCF-7乳腺癌细胞对纳米摇铃的内化过程，并且由于其强烈的近红外吸收，可作为用于局部热疗癌症治疗的高效光热换能器； 3）Tat功能化的SiO2壳不仅提高了生物相容性和细胞摄取效率，从而增强了抗癌功效，而且还可以防止AuNCs聚集并提供AuNCs的稳定性，从而使SERS信号可用于高保真度的细胞跟踪。报道的化学和设计的纳米结构应该会激发更多有趣的纳米结构和应用。
In this work, a novel type of nanomedical platform, the double-walled Au nanocage/ SiO2 nanorattle, is successfully fabricated by combining two "hollow-excavated strategies"-galvanic replacement and "surface-protected etching". The rational design of double-walled nanostructure based on gold nanocages (AuNCs) and hollow SiO2 shells functionalized respectively with p-aminothiophenol (pATP) and Tat peptide simultaneously renders the nanoplatforms three functionalities: 1) the whole nanorattle serves as a high efficient drug carrier thanks to the structural characteristics of AuNC and SiO2 shell with hollow interiors and porous walls; 2) the AuNC with large electromagnetic enhancement acts as a sensitive surface-enhanced Raman scattering (SERS) substrate to track the internalization process of the nanorattles by human MCF-7 breast cancer cells, as well as an efficient photothermal transducer for localized hyperthermia cancer therapy due to the strong near-infrared absorption; 3) Tat-functionalized SiO2 shell not only improves biocompatibility and cell uptake efficiency resulting in enhanced anticancer efficacy but also prevents the AuNCs from aggregation and provides the stability of AuNCs so that the SERS signals can be used for cell tracking in high fidelity. The reported chemistry and the designed nanostructures should inspire more interesting nanostructures and applications.