HLA polymorphism in Israel. 9. An overall comparative analysis.
HLA polymorphism in Israel. 9. An overall comparative analysis.
复制标题
以色列的 HLA 多态性。
作者：
B. Bonné;J. Bodmer;W. Bodmer;P. Pickbourne;C. Brautbar;E. Gazit;S. Nevo;R. Zamir
使用 11 个以色列人群和其他 9 个相关人群的 HLA 基因频率来计算遗传距离，以定量评估其相似性和差异。发现的最短距离是波兰犹太人和罗马尼亚犹太人之间的距离，而最大距离是俄罗斯犹太人和非洲黑人之间的距离。对主要人口群体内“平均”距离的估计表明，德系犹太人（波兰人、俄罗斯人、罗马尼亚人和德国人）比东欧非犹太人或中东人口（阿拉伯人、亚美尼亚人、黎巴嫩人和土耳其人）更加同质。德系犹太人和其他犹太社区之间的距离分布与他们的地理分布平行。然而，两个北非社区（利比亚人和摩洛哥人）之间相对较大的距离表明地理邻近并不一定与遗传相似性相关。犹太人口，尤其是德系犹太人，与邻近的非犹太人口显示出明显的差异，他们已经在这些非犹太人口中生活了许多世纪。 HLA 数据表明不同的犹太人群体有共同的起源。
HLA gene frequencies in 11 Israeli populations and nine other relevant populations were used to calculate genetic distances in a quantitative assessment of their similarities and differences. The shortest distance found is between Polish and Rumanian Jews, while the largest is between Russian Jews and Black Africans. Estimates of "average" distances within major population groups suggest that the Ashkenazi Jews (Poles, Russians, Rumanians and Germans) are a more homogeneous population than East European non-Jews or than Middle-Eastern populations (Arabs, Armenians, Lebanese and Turks). A cline of distances between Ashkenazi Jews and other Jewish communities parallels their geographic distribution; however, the relatively large distance between the two North African communities (Libyans and Moroccans) demonstrates that geographic proximity is not necessarily correlated with genetic similarity. The Jewish populations, especially the Ashkenazi, show a clear divergence from their neighboring non-Jewish populations, among whom they have lived for many centuries. There are indications in the HLA data of a common origin for the diverse Jewish populations.