Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (Ports)
Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (Ports)
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DOI：
10.1128/aac.43.8.2074
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发表时间：
1999-08-01
影响因子：
4.9
通讯作者：
Rubin, LG
中科院分区：
文献类型：
--
作者：
Anthony, TU;Rubin, LG
抗生素封管是一种治疗导管相关血流感染的方法，其中含有肝素和抗生素的溶液驻留在导管或输液港的管腔中。我们测试了万古霉素，头孢唑林，替卡西林-克拉维酸，头孢他啶，或环丙沙星与肝素在体外孵育后，在25或37摄氏度的时间间隔长达10天的生物测定的稳定性。除头孢他啶外，所有抗生素溶液在25和37 ℃下均保持大于或等于90%的活性。因此，研究停留时间长达10天的肝素-肝素封管液是可行的。
Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37 degrees C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime retained greater than or equal to 90% activity at both 25 and 37 degrees C. Thus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.