Synthesis and Functionalization of Inherently Chiral Tetraoxacalix[2]arene[2]pyridines
Synthesis and Functionalization of Inherently Chiral Tetraoxacalix[2]arene[2]pyridines
复制标题
固有手性四氧萼[2]芳烃[2]吡啶的合成与功能化
DOI：
10.1021/ol303019q
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发表时间：
2012-12-21
期刊：
影响因子：
5.2
通讯作者：
Wang, Mei-Xiang
中科院分区：
文献类型：
--
作者：
Pan, Shuai;Wang, De-Xian;Wang, Mei-Xiang
Inherently chiral tetraoxacalix[2]arene[2]pyridines containing C-2 symmetry were synthesized efficiently from a macrocyclic condensation reaction of resorcinol derivatives with 2,6-dichloro-3-nitropyridine in a one-pot reaction manner, while tetraoxacalix[2]arene[2]pyridine with an ABCD-substitution pattern was prepared in a good yield by means of a stepwise fragment coupling approach. Postmacrocyclization chemical manipulations led to functionalized tetraoxacalix[2]arene[2]pyridines. A racemic sample was resolved into enantiopure (+)- and (-)-inherently chiral compounds.
