Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.
Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man.
复制标题
补充 β-羟基-β-甲基丁酸 (HMB) 和 α-酮异己酸 (KIC) 可减少人体运动引起的肌肉损伤的体征和症状。
DOI：
--
复制
发表时间：
2005
影响因子：
2.5
通讯作者：
G. Howatson
中科院分区：
文献类型：
--
作者：
K. van Someren;A. J. Edwards;G. Howatson
本研究探讨了补充β-羟基-β-甲基丁酸酯(HMB)和α-酮基异己酸(KIC)对单次偏心阻力运动后运动性肌肉损伤的体征和症状的影响。六名非阻力训练的男性受试者在两个不同的场合进行了旨在诱导肌肉损伤的锻炼方案，在平衡交叉设计中，在优势臂或非优势臂上进行。在平衡交叉设计中，受试者在锻炼前14天被分配到HMB/KIC(每天3g HMB和0.3gα-酮基异己酸)或安慰剂治疗。分别于运动前、运动后1h、运动后2 4h、运动后48h、运动后72h测定1次重复最大重复次数(1Rm)、血浆肌酸激酶活性(CK)、延迟性肌肉酸痛(DOMS)、肢体周长和运动范围(ROM)。DOM和1RM、肢体周长和活动度的百分比变化在72小时内都发生了变化(P<；0.05)。补充HMB//IC可降低CK反应、减少1rM的百分比和增加肢体周长的百分比(P<；0.05)。此外，在HMB/KIC治疗中，运动后24小时DOMS降低(P<；0.05)。总而言之，补充14天的HMB和KIC减少了在单次偏心阻力运动后，未接受抗阻训练的男性的运动性肌肉损伤的体征和症状。
This study examined the effects of beta-hydroxyl-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) supplementation on signs and symptoms of exercise-induced muscle damage following a single bout of eccentrically biased resistance exercise. Six non-resistance trained male subjects performed an exercise protocol designed to induce muscle damage on two separate occasions, performed on the dominant or non-dominant arm in a counter-balanced crossover design. Subjects were assigned to an HMB/KIC (3 g HMB and 0.3 g alpha-ketoisocaproic acid, daily) or placebo treatment for 14 d prior to exercise in the counter-balanced crossover design. One repetition maximum (1RM), plasma creatine kinase activity (CK), delayed onset muscle soreness (DOMS), limb girth, and range of motion (ROM) were determined pre-exercise, at 1h, 24 h, 48 h, and 72 h post-exercise. DOMS and the percentage changes in 1RM, limb girth, and ROM all changed over the 72 h period (P < 0.05). HMB//IC supplementation attenuated the CK response, the percentage decrement in 1RM, and the percentage increase in limb girth (P < 0.05). In addition, DOMS was reduced at 24 h post-exercise (P < 0.05) in the HMB/KIC treatment. In conclusion, 14 d of HMB and KIC supplementation reduced signs and symptoms of exercise-induced muscle damage in non-resistance trained males following a single bout of eccentrically biased resistance exercise.