Contents lists available at ScienceDirect The International Journal of Biochemistry & Cell Biology
Contents lists available at ScienceDirect The International Journal of Biochemistry & Cell Biology
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发表时间：
2011
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通讯作者：
A. Vaughan;A. Roghanian;M. Cragg
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作者：
A. Vaughan;A. Roghanian;M. Cragg
免疫系统涉及许多不同细胞类型之间复杂的相互作用。在过去的十年中，T细胞、树突状细胞（DC）和巨噬细胞都被认为是免疫反应的关键调节细胞，连接先天免疫和适应性免疫。在这个讨论中被遗忘的细胞是b细胞。长期以来被认为是由t细胞支配的简单抗体生产单位，近年来开始改变这种假设。许多b细胞亚群的存在，具有能够调节t细胞和慢性炎症反应的特定调节功能的发现，揭示了b细胞迄今为止未被认识的作用。特别是，这些想法是根据抗cd20抗体利妥昔单抗在自身免疫环境中消耗b细胞后令人惊讶的成功反应而发展起来的。在这里，我们总结了不起眼的b细胞的历史，并讨论了一些最近的关键发现，这些发现使我们提出它是正在进行的免疫反应的重要调节剂，因此，它是免疫宇宙的大师之一。
The immune system involves the complex interplay between many different cell types. Over the last decade, T cells, dendritic cells (DC) and macrophages have all been implicated as the key regulator cells of the immunological response, linking innate and adaptive immunity. The forgotten cell in this discourse has been the B-cell. Long considered as simple antibody production units dictated to by T-cells, recent years have begun to shift this assumption. The discovery that numerous B-cell subsets exist, with specific regulatory functions capable of modulating T-cell and chronic inflammatory responses has revealed a hitherto unappreciated role of B-cells. In particular, these ideas have been developed in light of the surprisingly successful responses delivered in autoimmune settings following depletion of B-cells with the anti-CD20 antibody rituximab. Here we summarise the history of the humble B-cell and discuss some of the key recent findings that lead us to propose it as an important regulator of ongoing immune responses and as such, one of the masters of the immunoverse.