Dynamic gadolinium uptake in thermally treated canine brain tissue and experimental cerebral tumors.
Dynamic gadolinium uptake in thermally treated canine brain tissue and experimental cerebral tumors.
复制标题
热处理犬脑组织和实验性脑肿瘤中的动态钆摄取。
DOI：
10.1097/00004424-200302000-00005
复制
发表时间：
2003
影响因子：
6.7
通讯作者：
Hazle,JohnD
中科院分区：
文献类型：
--
作者：
Kangasniemi,Marko;Stafford,RJason;Price,RogerE;Jackson,EdwardF;Hazle,JohnD
Kangasniemi M，斯塔福德RJ，Price RE等人，热处理犬脑组织和实验性脑肿瘤中的动态钆摄取。2003年投资无线电三十八：102- 107.原理和目的：脑肿瘤的热凝固引起邻近脑组织的反应性变化，在MR图像中表现为Gd-DTPA增强。这使得难以通过放射学确定治疗成功的评估，因为反应性变化可以模拟残留肿瘤。动态Gd-DTPA摄取曲线在反应性组织和肿瘤进行了研究，以评估对比增强（CE）-动态MRI的效用，以区分反应性的变化，从残留的肿瘤在犬model.Materials和Methods.Cerebral热坏死，诱导使用980 nm激光在11只狗脑内传染性性病肿瘤（TVT）。快速自旋回波T1加权成像序列用于CE动态MRI。Gd-DTPA摄取数据采集与10秒的时间分辨率和未经处理的TVT的反应tissue.Results.Characteristic钆摄取曲线进行测量和表征的反应性脑组织，未经处理和治疗的TVT。反应性脑组织的早期和延迟动态反应与TVT.Conclusion.Reactive热变化，否则正常脑组织，可以区分脑热治疗后残留的肿瘤，使用CE动态MRI。
Kangasniemi M, Stafford RJ, Price RE, et al. Dynamic gadolinium uptake in thermally treated canine brain tissue and experimental cerebral tumors. Invest Radiol 2003; 38: 102–107.Rationale and Objectives.Thermal coagulation of cerebral tumors induces reactive changes within adjacent brain tissue, which appear as Gd-DTPA enhancement in MR images. This makes assessment of therapeutic success difficult to establish radiographically because the reactive changes can mimic residual tumor. Dynamic Gd-DTPA uptake curves in reactive tissue and tumor were investigated to assess the utility of contrast enhanced (CE)-dynamic MRI to distinguish reactive changes from residual tumor in a canine model.Materials and Methods.Cerebral thermal necrosis was induced using a 980 nm laser in 11 dogs with intracerebral transmissible venereal tumors (TVTs). A fast spin-echo T1-weighted imaging sequence was used for CE-dynamic MRI. Gd-DTPA uptake data were acquired with 10-second temporal resolution and for untreated TVTs for reactive tissue using a sigmoidal-exponential model.Results.Characteristic gadolinium uptake curves were measured and characterized for reactive brain tissue, and untreated and treated TVTs. Both early and delayed dynamic responses were significantly different in reactive brain tissue compared with TVT.Conclusion.Reactive thermal changes in otherwise normal brain tissue can be distinguished from residual tumor after cerebral thermal therapy using CE-dynamic MRI.