More Than 12 % Polarization and 20 Minute Lifetime of 15 N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
More Than 12 % Polarization and 20 Minute Lifetime of 15 N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
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DOI：
10.1002/anie.201804185
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发表时间：
2018-07
影响因子：
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通讯作者：
Jeffrey McCormick;S. Korchak;S. Mamone;Y. N. Ertas;Zhiyu Liu;Luke Verlinsky;S. Wagner;S. Glöggler-S.-Gl
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文献类型：
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作者：
Jeffrey McCormick;S. Korchak;S. Mamone;Y. N. Ertas;Zhiyu Liu;Luke Verlinsky;S. Wagner;S. Glöggler-S.-Gl
超极化技术是扩展MRI在体内研究结构、功能和代谢过程的能力的关键。最近非均相催化剂的开发已经在水中产生了高度极化，使用的是仲氢和生物相关的造影剂。介绍了一种非均相配体稳定的Rh催化剂，通过将神经氨酸氢化成胆碱衍生物，该催化剂能够获得12.2±2.7%的15N极化。这是迄今为止在水中使用的所有仲氢方法中最高的15N极化。值得注意的是，这是使用具有21.0±0.4分钟的超长自旋-晶格弛豫时间(T1)的氢化季胺进行的。这些结果为使用无毒的相似模型系统进行15N活体成像打开了大门，因为生产介质的生物相容性和使用对氢诱导极化(PhIP)作为超极化方法的多相催化剂的稳定性。
Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand-stabilized Rh catalyst is introduced that is capable of achieving 15 N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15 N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin-lattice relaxation time (T1 ) of 21.0±0.4 min. These results open the door to the possibility of 15 N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen-induced polarization (PHIP) as the hyperpolarization method.