Acupuncture: A novel hypothesis for the involvement of purinergic signalling
Acupuncture: A novel hypothesis for the involvement of purinergic signalling
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DOI：
10.1016/j.mehy.2009.05.031
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发表时间：
2009-10-01
影响因子：
4.7
通讯作者：
Burnstock, Geoffrey
中科院分区：
文献类型：
--
作者：
Burnstock, Geoffrey
图1中示意性地概括了该假设。提出了通过针和施加热或电流使皮肤机械变形导致从皮肤中的角质形成细胞、成纤维细胞和其它细胞释放大量ATP;然后ATP占据在皮肤和舌头中的感觉神经末梢上表达的特定受体亚型;感觉神经通过神经节向脊髓、脑干、下丘脑和高级中枢发送脉冲;脑干和下丘脑含有控制自主功能的神经元，包括心血管、胃肠、呼吸、泌尿生殖和肌肉骨骼活动。皮肤感觉纤维中产生的脉冲与中间神经元连接，以调节（抑制或促进）脑干和下丘脑中运动神经元的活动，从而改变自主神经功能;通过中间神经元，特别激活的感觉神经也抑制了通往皮层疼痛中心的神经通路。(C)2009爱思唯尔有限公司保留所有权利。
The hypothesis is summarised schematically in Fig. 1.It is proposed that mechanical deformation of the skin by needles and application of heat or electrical current leads to release of large amounts of ATP from keratinocytes, fibroblasts and other cells in skin; the ATP then occupies specific receptor subtypes expressed on sensory nerve endings in the skin and tongue; the sensory nerves send impulses through ganglia to the spinal cord, the brain stem, hypothalamus and higher centres; the brain stem and hypothalamus contain neurons that control autonomic functions, including cardiovascular, gastrointestinal, respiratory, urinogenital and musculo-skeletal activity. Impulses generated in sensory fibres in the skin connect with interneurons to modulate (either inhibition or facilitation) the activities of the motoneurons in the brain stem and hypothalamus to change autonomic functions; specifically activated sensory nerves, via interneurons, also inhibit the neural pathways to the pain centres in the cortex. (C) 2009 Elsevier Ltd. All rights reserved.