Racial differences in stage and survival in head and neck squamous cell carcinoma
Racial differences in stage and survival in head and neck squamous cell carcinoma
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DOI：
10.1097/mlg.0b013e318033c800
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发表时间：
2007-05-01
期刊：
影响因子：
2.6
通讯作者：
Bhattacharyya, Neil
中科院分区：
文献类型：
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作者：
Nichols, Anthony C.;Bhattacharyya, Neil
目标.本研究的目的是描述黑人和白色头颈部鳞状细胞癌（HNSCCA）患者的生存差异。设计从监测、流行病学和最终结果（SEER）数据库（1988-2002年）中提取黑人患者或白色患者的口腔舌和声门SCCA病例。对于每个主要站点，TNM分期进行插补，并比较种族之间的分期分布。对于每一个黑人患者，随机选择一个白色对照组，在诊断时的年龄、性别、分期、手术治疗和放射治疗方面进行匹配。然后对匹配对进行总体和疾病特异性生存期的Kaplan-Meier生存比较。结果从1，919例口腔舌癌患者中提取了151例黑人和1，768例白色患者的舌癌细胞。黑人患者在初次就诊时T分期（P =.001）和N分期（P =.002）显著升高。在声门癌中，提取了4，578例病例（625例黑人和3，953例白色患者）。黑人患者再次出现T分期显著升高（P
Objectives. The goal of this study was to characterize differences in survival between black patients and white patients with squamous cell carcinoma of the head and neck (HNSCCA). Design. Cases of oral tongue and glottic SCCA in black patients or white patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (years 1988-2002). For each primary site, TNM staging was imputed, and staging distributions were compared between races. For each black patient, a randomly selected white control was matched for age at diagnosis, sex, stage, surgical treatment, and radiation. Kaplan-Meier survival comparisons for both overall and disease-specific survival were then conducted for the matched pairs. Results. From 1,919 cases of carcinoma of the oral tongue, those of 151 black and 1,768 white patients were extracted. Black patients had a significantly elevated T stage (P =.001) and N stage (P =.002) at primary presentation. Of glottic carcinoma, 4,578 cases (625 black and 3,953 white patients) were extracted. Black patients again presented with significantly elevated T stage (P