Cell lineages and early patterns of embryonic CNS vascularization
Cell lineages and early patterns of embryonic CNS vascularization
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DOI：
10.4161/cam.3.2.7855
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发表时间：
2009-04-01
影响因子：
3.2
通讯作者：
Kurz, Haymo
中科院分区：
文献类型：
--
作者：
Kurz, Haymo
高等脊椎动物的中枢神经系统（CNS）血管形成和模式的第一步提出。与胚胎中枢神经系统（未分段的脊髓与分段的脑原纤维）及其周围（分段的躯干与未分段的头部中胚层、神经嵴来源的间质）的区域多样性相对应，不同来源的细胞有助于内皮细胞和壁细胞群的形成。内皮细胞的自主迁移潜能是由吸引和排斥的线索引导的。然而，脊髓和前脑血管形成的共同模式是，主要的腹侧血管芽供应神经管的心室周围血管丛，而背侧血管芽出现较晚。
First steps of blood vessel formation and patterning in the central nervous system (CNS) of higher vertebrates are presented. Corresponding to the regional diversity of the embryonic CNS (unsegmented spinal cord vs segmented brain anlagen) and its surroundings (segmented trunk vs unsegmented head mesoderm, neural crest-derived mesenchyme), cells of different origins contribute to the endothelial and mural cell populations. The autonomous migratory potential of endothelial cells is guided by attractive and repulsive clues. Nevertheless, a common pattern in both spinal cord and forebrain vascularization appears, with primary ventral vascular sprouts supplying the periventricular vascular plexus of the neural tube, whereas dorsolateral sprouts appear later.