Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy.
Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy.
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DOI：
10.1186/s12884-018-1913-z
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发表时间：
2018-07-06
影响因子：
3.1
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Mei Y;Lin Y;Luo D;Gao L;He L
该研究的主要目的是调查妊娠期肝内胆汁淤积 (ICP) 合并单绒毛膜双羊膜 (MCDA) 双胎妊娠的围产期结局。本研究是一项针对 ICP 和 MCDA 双胎妊娠女性的回顾性观察研究。将纳入病例分为轻度ICP组（10~39mmol/L）和重度ICP组（> = 40mmol/L），比较两组的围生结局，并评估不良围生结局的预测因素。轻度ICP组37例，重度ICP组21例，其中重度ICP组妊娠期糖尿病（GDM）和医源性早产的发生率均高于轻度ICP组。诊断 ICP< 32 周时的孕龄 (GA) 是< 35 周分娩时 GA 以及新生儿综合不良结局的独立危险因素。总胆汁酸 (TBA) > 40 mmol/l 是胎便染色羊水的独立危险因素。对于 ICP 和 MCDA 双胎妊娠的妇女，诊断 ICP < 32 周时的 GA 和 TBA > 40umol/L 与不良围产期结局相关。
The primary aim of the study is to investigate the perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP) with monochorionic diamniotic (MCDA) twin pregnancy. This study is a retrospective observational study for women with ICP and MCDA twin pregnancy. Included cases were divided into mild ICP group (10–39 mmol/L) and severe ICP group (> = 40 mmol/L), whose perinatal outcomes were compared between this two groups and whose predictors of adverse perinatal outcomes were evaluated. 37 cases and 21 cases are in mild and severe ICP group respectively, of which, the incidence of gestational diabetes mellitus (GDM) and iatrogenic preterm delivery in severe ICP group are higher than those in mild ICP group. Gestational age (GA) at diagnosis of ICP < 32 weeks is an independent risk factor for GA at delivery < 35 weeks and for composite adverse neonatal outcome. Total bile acids (TBA) > 40 mmol/l is an independent risk factor for meconium-stained amniotic fluid. For women with ICP and MCDA twin pregnancy, GA at diagnosis of ICP < 32 weeks and TBA > 40umol/L are associated with adverse perinatal outcomes.
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