Mood disturbances in motor neurone disease
Mood disturbances in motor neurone disease
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DOI：
10.1016/s0022-510x(98)00203-2
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发表时间：
1998-10-01
影响因子：
4.4
通讯作者：
Shaw, PJ
中科院分区：
文献类型：
--
作者：
Moore, MJ;Moore, PB;Shaw, PJ
这项研究探索了运动神经元疾病患者经历的抑郁和焦虑的严重程度，并试图将其与疾病进展、最近的生活事件和人格因素联系起来。使用贝克抑郁问卷和医院焦虑和抑郁量表对18名参与研究的患者进行了精神症状评估。用Norris量表和Holmes和Rahe社会适应评定量表测量疾病的严重程度和病程中的生活事件。采用艾森克人格问卷(EPQ)进行人格测评。在参与研究的18名患者中，只有4名(23%)患有抑郁症，其中3名(17%)为轻度，1名(6%)为中度。另有6名患者(33%)被评为交界性抑郁症。只有两名患者处于焦虑状态，两人都同时患有轻度抑郁。未发现抑郁与生活事件或疾病进展相关。只有艾森克人格问卷的L分量表(15.6+/-4.9)超出了一般人群的预期。尽管在疾病过程中，生活事件的严重性和频率很高，但大多数患者并不会发展为抑郁症。这一出人意料的结果的原因尚不清楚。抑郁症被认为是由于5-羟色胺能神经递质系统活动不足所致。然而，与痴呆症和其他神经退行性疾病相比，MND患者的这一系统相对不受影响。患者L的高分表明，许多人可能通过广泛使用否认作为一种心理防御来应对自己的疾病。(C)1998年，爱思唯尔科学公司出版。保留所有权利。
This study explores the severity of depression and anxiety experienced by patients suffering from motor neurone disease and seeks to link this to illness progression, recent life events and personality factors. The 18 patients who participated in the study were assessed for the presence of psychiatric symptoms using the Beck Depressive Inventory and the Hospital Anxiety and Depression Scale. The severity of the illness and the life events during the course of the illness were measured using the Norris scale and the Holmes and Rahe Social Readjustment Rating Scale. A personality assessment was made using the Eysenck Personality Questionnaire (EPQ). Only four out of these 18 patients (23%) in the study suffered depression and of these three (17%) were mild and one (6%) was of moderate severity. A further six patients (33%) were rated as borderline depression. Only two patients suffered from an anxiety state and both had concurrent mild depression. No correlations of depression were found with the life events or illness progression. Only the L sub-scale of the EPQ (15.6+/-4.9) exceeds values expected for the general population. Despite the severity and frequency of life events during the course of the illness, most patients do not develop a depressive illness. The reason for this unexpected result is unclear. Depression is believed to result from underactivity of the serotonergic neurotransmitter system. However, in MND this system is relatively unaffected in contrast to dementia and other neurodegenerative disorders. The patients' high L scores suggest that many may cope with their illness by widespread use of denial as a psychological defence. (C) 1998 Published by Elsevier Science B.V. All rights reserved.