PULMONARY-FUNCTION IN MEN AFTER OXYGEN BREATHING AT 3.0 ATA FOR 3.5 H
PULMONARY-FUNCTION IN MEN AFTER OXYGEN BREATHING AT 3.0 ATA FOR 3.5 H
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DOI：
10.1152/jappl.1991.71.3.878
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发表时间：
1991-09-01
影响因子：
3.3
通讯作者：
UNGER, M
中科院分区：
文献类型：
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作者：
CLARK, JM;JACKSON, RM;UNGER, M
作为预测性研究V的肺部分，旨在确定人体多器官和系统在3.0-1.5 ATA下的O2耐受性，在1.0 ATA下对13名健康男性在3.0 ATA下暴露于O2 3.5 h前后的肺功能进行了评价。 测量包括流量-容积环、肺量测定和气道阻力（Raw）（n = 12）; CO弥散量（n = 11）;闭合容积（n = 6）;以及空气与HeO 2强制肺活量操作（n = 5）。 大多数受试者在暴露期间出现轻度胸部不适、咳嗽和呼吸困难。 运动后1秒用力呼气量（FEV 1）和肺活量25-75%时的用力呼气流量（FEF 25 -75）分别显著降低5.9%和11.8%，而用力肺活量无显著变化。 在50%肺活量时，空气和HeO 2的最大呼气中段流速的平均差异显著降低18%。 暴露后原始和CO弥散量没有改变。 与FEV 1相比，FEF 25 -75相对较大的变化、流量密度依赖性的降低以及正常的Raw呼气后均与外周气道中的流量限制一致，这是观察到的呼气流量降低的主要原因。 将1例在暴露3.0 h时发生惊厥的受试者的暴露后肺功能变化与12例未发生惊厥的受试者的相应平均变化进行比较。
As a pulmonary component of Predictive Studies V, designed to determine O2 tolerance of multiple organs and systems in humans at 3.0-1.5 ATA, pulmonary function was evaluated at 1.0 ATA in 13 healthy men before and after O2 exposure at 3.0 ATA for 3.5 h. Measurements included flow-volume loops, spirometry, and airway resistance (Raw) (n = 12); CO diffusing capacity (n = 11); closing volumes (n = 6); and air vs. HeO2 forced vital capacity maneuvers (n = 5). Chest discomfort, cough, and dyspnea were experienced during exposure in mild degree by most subjects. Mean forced expiratory volume in 1 s (FEV1) and forced expiratory flow at 25-75% of vital capacity (FEF25-75) were significantly reduced postexposure by 5.9 and 11.8%, respectively, whereas forced vital capacity was not significantly changed. The average difference in maximum midexpiratory flow rates at 50% vital capacity on air and HeO2 was significantly reduced postexposure by 18%. Raw and CO diffusing capacity were not changed post-exposure. The relatively large change in FEF25-75 compared with FEV1, the reduction in density dependence of flow, and the normal Raw postexposure are all consistent with flow limitation in peripheral airways as a major cause of the observed reduction in expiratory flow. Postexposure pulmonary function changes in one subject who convulsed at 3.0 h of exposure are compared with corresponding average changes in 12 subjects who did not convulse.