How, and from which cell sources, do nevi really develop?
How, and from which cell sources, do nevi really develop?
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DOI：
10.1111/exd.12363
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发表时间：
2014-05-01
影响因子：
3.6
通讯作者：
Hatzistergos, Konstantinos E.
中科院分区：
文献类型：
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作者：
Grichnik, James M.;Ross, Andrew L.;Hatzistergos, Konstantinos E.
黑素细胞肿瘤是一组不同的良性和恶性肿瘤，具有不同的临床特征。虽然一些模型仍然认为表皮黑素细胞是黑素细胞肿瘤的起源，但大多数肿瘤的临床发现与这一理论不一致。尽管在痣和黑色素瘤生物学方面取得了进展，但起源细胞的位置和分化状态仍不明确。种系遗传学、突变细胞的生物学状态和细胞位置以及局部环境因素都可能在黑色素细胞肿瘤的发生发展中发挥作用。在此，我们将回顾黑色素细胞瘤的潜在模型，并讨论研究的挑战和机遇。
Melanocytic neoplasms are a diverse group of benign and malignant tumors with variable clinical features. While some models still promote the epidermal melanocyte as the origin of melanocytic neoplasms, clinical findings are inconsistent with this theory for the majority of tumors. Despite advances in naevus and melanoma biology, the location and differentiation status of the cell of origin remains undefined. Germ line genetics, biological state and cellular location of the mutated cell, as well as local environmental factors all likely play a role in the development of melanocytic neoplasms. Herein, we will review potential models for melanocytic neoplasia and discuss research challenges and opportunities.