Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination
Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination
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DOI：
10.1038/nm0498-421
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发表时间：
1998-04-01
期刊：
影响因子：
82.9
通讯作者：
Wain-Hobson, S
中科院分区：
文献类型：
--
作者：
Cheynier, R;Gratton, S;Wain-Hobson, S
研究了抗原刺激对猴免疫缺陷病毒（SIV）复制动力学的影响。在对纯化的M.在结核病中，注意到一种独特的SIV变体，可能是由于活化的抗原特异性T细胞克隆的浸润，而不是原位的血源性病毒感染。外周血中SIV准种的动态表明病毒复制的连续波，说明抗原刺激作为病毒传播和发病机制的驱动力的作用。
The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCC inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.