Analysis of Biochemical Features of Hepatitis B Virus Infected Patients in Southwest China
Analysis of Biochemical Features of Hepatitis B Virus Infected Patients in Southwest China
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DOI：
10.7754/clin.lab.2016.160140
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发表时间：
2016-01-01
影响因子：
0.7
通讯作者：
Zhang, A-Mei
中科院分区：
文献类型：
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作者：
Song, Yuzhu;Shen, Yunsong;Zhang, A-Mei
背景资料：B型肝炎是我国最常见的传染病之一，对HBV感染者的生化指标进行研究是十分必要的。方法：对西南地区1765例HBV感染者和840例一般对照者的生化及基本特征进行分析。合并感染丙型肝炎病毒（HCV）和梅毒螺旋体（TPa）的患者合并感染率仅为0.3%。绝大多数患者（1081人）处于恢复期，急性期和慢性期分别占4.2%和34.6%。HBV感染者肝功能指标与正常对照组比较差异有统计学意义。为了进一步研究不同阶段HBV患者生化特征的变化，将他们分为三组（样品#1：急性感染期患者;样品#2：慢性感染期患者;样品#3：恢复期患者）。除总蛋白和珠蛋白外，其他肝功能指标在三组间差异均有统计学意义。总蛋白和白蛋白从恢复期、慢性HBV感染者到急性HBV感染者逐渐下降。结论：生化指标可用于评价HBV感染的进展和治疗效果。本研究首次报道了西南地区HBV感染者的基本情况和生化指标。
Background: Hepatitis B is one of the most common infectious diseases in China, and it is necessary to study biochemical indicators of HBV infected patients.Methods: Biochemical and basic features of 1765 HBV infected patients and 840 general controls were collected and analyzed from Southwest China.Results: A total of 23.5% of the patients were children or young persons (less than 40 years old). The co-infected rate was only 0.3% for those who were co-infected with Hepatitis C virus (HCV) or Treponema pallidum (TPa). Most of patients (1081 individuals) were under convalescent condition, and 4.2% and 34.6% HBV patients were at acute and chronic phase, respectively. The indicators of liver function were significantly different between HBV patients and normal controls. En order to further study the variation of biochemical features in HBV patients in different phase, they were divided into three groups (sample #1: patients in acute infected phase; sample #2: patients in chronic infected phase; and sample #3: patients in convalescent condition). Excluding total protein and globin, all other indicators of liver function were statically different among the three groups. Total protein and albumin gradually decreased from convalescent patients, chronic HBV-infected patients, to acute HBV-infected patients.Conclusions: Biochemical features could be used to evaluate the progress and therapeutic effects of HBV-infection. Our analysis firstly reported basic and biochemical information of HBV patients in Southwest China.