Nucleus Accumbens Local Circuit for Cue-Dependent Aversive Learning.
Nucleus Accumbens Local Circuit for Cue-Dependent Aversive Learning.
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伏核局部回路用于依赖线索的厌恶学习。
DOI：
10.1101/2023.02.06.527338
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Francis,TChase
中科院分区：
文献类型：
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作者：
Belilos,Andrew;Gray,Cortez;Sanders,Christie;Black,Destiny;Mays,Elizabeth;Richie,ChristopherT;Sengupta,Ayesha;Hake,HollyS;Francis,TChase
对威胁性环境刺激的响应需要检测和编码决定威胁的重要环境特征。厌恶事件非常显着，这促进了对表明这种威胁的刺激的联想学习。伏隔核具有独特的位置，可以通过大脑区域主要投射神经元的可塑性来处理这种显着的、令人厌恶的信息并促进积极的输出。我们描述了伏隔核核心局部回路，其中兴奋可塑性有助于学习和回忆离散的厌恶线索。我们证明，假定的伏核 P 物质释放和表达多巴胺 2 受体的投射神经元的长期兴奋可塑性是线索依赖性恐惧学习所必需的。此外，我们发现恐惧学习和回忆取决于不同的投射神经元亚型。我们的工作证明了伏隔核 P 物质在线索依赖性厌恶学习中的关键作用。
Response to threatening environmental stimuli requires detection and encoding of important environmental features that dictate threat. Aversive events are highly salient, which promotes associative learning about stimuli that signal this threat. The nucleus accumbens is uniquely positioned to process this salient, aversive information and promote motivated output, through plasticity on the major projection neurons in the brain area. We describe a nucleus accumbens core local circuit whereby excitatory plasticity facilitates learning and recall of discrete aversive cues. We demonstrate that putative nucleus accumbens substance P release and long-term excitatory plasticity on dopamine 2 receptor-expressing projection neurons are required for cue-dependent fear learning. Additionally, we find that fear learning and recall is dependent on distinct projection neuron subtypes. Our work demonstrates a critical role for nucleus accumbens substance P in cue-dependent aversive learning.