Apoptosis - a significant cause of bone cell death in osteonecrosis of the femoral head
Apoptosis - a significant cause of bone cell death in osteonecrosis of the femoral head
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DOI：
10.1302/0301-620x.86b8.14834
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Polak, JM
中科院分区：
文献类型：
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作者：
Calder, JDF;Buttery, L;Polak, JM
股骨头坏死通常影响年轻人，占全髋关节置换术的12%。骨细胞死亡的潜在病理生理学仍不确定。我们研究了一氧化氮介导的细胞凋亡作为一种潜在的机制，发现类固醇和酒精诱导的骨坏死伴随着成骨细胞和骨细胞的广泛凋亡。某些药物或其代谢产物可能对股骨头的松质骨具有直接的细胞毒性作用，导致细胞凋亡而不是单纯的坏死。
Osteonecrosis of the femoral head usually affects young individuals and is responsible for up to 12% of total hip arthroplasties. The underlying pathophysiology of the death of the bone cells remains uncertain. We have investigated nitric oxide mediated apoptosis as a potential mechanism and found that steroid- and alcohol-induced osteonecrosis is accompanied by widespread apoptosis of osteciblasts and osteocytes. Certain drugs or their metabolites may have a direct cytotoxic effect on cancellous bone of the femoral head leading to apoptosis rather than purely necrosis.