Chronic herpes simplex virus type-2 infection and HIV viral load
Chronic herpes simplex virus type-2 infection and HIV viral load
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DOI：
10.1258/095646205774763298
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发表时间：
2005-11-01
影响因子：
1.4
通讯作者：
Downing, R
中科院分区：
文献类型：
--
作者：
Duffus, WA;Mermin, J;Downing, R
截至2003年12月，撒哈拉以南非洲成人艾滋病毒/艾滋病流行率估计为7.5- 8.5%，30岁以上成人中单纯疱疹病毒2型感染率为60%至82%。然而，很少有人知道HIV/HSV-2合并感染的自然史在这一人群中。我们在一项对未接受抗逆转录病毒治疗的HIV感染者进行的横断面研究中，评估了有和无慢性HSV-2合并感染者的HIV病毒载量和CD 4+细胞计数。HSV-2和HIV合并感染者与无HSV-2感染者相比，HIV病毒载量高0.3 log拷贝/mL（P=0.014）。慢性HSV-2感染可能对HIV感染者的临床病程产生负面影响。
By December 2003, the estimated adult HIV/AIDS prevalence rate in sub-Saharan Africa was 7.5-8.5%, and rates of herpes simplex virus type-2 (HSV-2) infection among adults aged > 30 years ranged from 60% to 82%. However, little is known about the natural history of HIV/HSV-2 co-infection in this population. We evaluated HIV viral load and CD4+ cell counts among persons with and without chronic HSV-2 co-infection in a cross-sectional study of HIV-infected persons not receiving antiretroviral therapy. HSV-2 and HIV co-infection was associated with a 0.3 log copies/mL higher HIV viral load compared with persons without HSV-2 infection (P=0.014). Chronic HSV-2 infection may have a negative effect on the clinical course of persons with HIV.