Possible Involvement of Free Radicals in Lipopolysaccharide-Induced Labyrinthitis in the Guinea Pig: A Morphological and Functional Investigation

Possible Involvement of Free Radicals in Lipopolysaccharide-Induced Labyrinthitis in the Guinea Pig: A Morphological and Functional Investigation
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自由基可能参与脂多糖诱导的豚鼠迷路炎：形态学和功能研究

DOI：
10.1159/000027605
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发表时间：
1998
期刊：
ORL
影响因子：
--
通讯作者：
R. Popa
R. Popa
中科院分区：
--
文献类型：
--
作者：
M. Takumida;M. Anniko;R. Popa

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鼓室内注射细菌脂多糖可损害豚鼠的热量反应，并对前庭末梢器官和内淋巴囊造成严重和广泛的形态损害。这些作用可被一氧化氮合酶竞争性抑制剂N-硝基-L-精氨酸甲酯、O2清除剂超氧化物歧化酶、地塞米松和过氧亚硝酸根清除剂依布硒所阻断。这些观察表明，一氧化氮和超氧化物的生成增加，导致过氧亚硝酸盐的形成，可能是导致前庭病理损害的一个重要因素。如果是这样的话，我们可能已经找到了一种研究内耳疾病前庭发病机制的方法。
Intratympanic injection of bacterial lipopolysaccharide impaired caloric responses and caused severe and widespread morphological damage to vestibular end organs and the endolymphatic sac in the guinea pig. These effects could be blocked with N-nitro-L-arginine methylester, a competitive inhibitor of nitric oxide synthase, with superoxide dismutase, an O2 scavenger, with dexamethasone, and with ebselen, a scavenger of peroxynitrite. These observations indicate that enhanced nitric oxide and superoxide production, resulting in formation of peroxynitrite, is probably an important factor responsible for the pathological damage to vestibuli. If this is so, we may have found a way to study vestibular pathogenesis in inner ear disease.
Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.
DOI： 10.1016/s0021-9258(18)47024-x
发表时间： 1994-11
期刊： The Journal of biological chemistry
影响因子： --
作者：
Jean-Luc BalligandS;Dan Ungureanu-LongroisSg;William;-W.;Simmons;David Pimental;Tadeusz A. Malinskin;Matthias Kapturczakn;Ziad Tahan;Charles;Lowensteinll;Amy;DavidoP;Ralph;Kelly;Thomas;Smith;Thomas MichelSS
通讯作者： Jean-Luc BalligandS;Dan Ungureanu-LongroisSg;William;-W.;Simmons;David Pimental;Tadeusz A. Malinskin;Matthias Kapturczakn;Ziad Tahan;Charles;Lowensteinll;Amy;DavidoP;Ralph;Kelly;Thomas;Smith;Thomas MichelSS
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
一氧化氮、超氧化物和过氧亚硝酸盐：好的、坏的和丑陋的。
DOI： 10.1152/ajpcell.1996.271.5.c1424
发表时间： 1996
期刊： The American journal of physiology
影响因子： --
作者：
Beckman,JS;Koppenol,WH
通讯作者： Koppenol,WH