Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure
Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure
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DOI：
10.1081/clt-120025356
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Yu, CC
中科院分区：
文献类型：
--
作者：
Lin, NC;Lin, JL;Yu, CC
本文介绍了一名皮肤接触百草枯的严重中毒患者，他有超过10%的体表面积的化学烧伤，暴露后60小时血清百草枯水平为0.13 μ g/mL，并出现严重低氧血症（PaO 2 41.6 mmHg）。患者成功接受了初始大剂量环磷酰胺（15 mg/kg/天，共2天）联合重复甲基强的松龙脉冲治疗（15 mg/kg/天，共6天）和连续地塞米松给药（每8小时5 mg），3个月后完全恢复，无后遗症。这种治疗方法值得在未来的临床试验中进一步研究。
The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 mug/mL 60 hr after exposure, and severe hypoxemia (PaO2 41.6 mmHg). The patient was successfully treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), and recovered completely without sequelae 3 months later. This treatment deserves further investigation in future clinical trials.