Chronotype and sex effects on sleep architecture and quantitative sleep EEG in healthy young adults
Chronotype and sex effects on sleep architecture and quantitative sleep EEG in healthy young adults
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DOI：
10.1093/sleep/28.7.819
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发表时间：
2005-07-01
期刊：
影响因子：
5.6
通讯作者：
Dumont, M
中科院分区：
文献类型：
--
作者：
Mongrain, V;Carrier, J;Dumont, M
研究目的：评价生理时钟类型的影响当对睡眠时间表的限制最小并且考虑性别差异时，对睡眠阶段和定量睡眠脑电图（早晨类型和晚上类型）的影响。设计：在实验室中进行48小时的会话，包括2个晚上的多导睡眠描记术，之前进行7天的动态活动描记术。设置：时间生物学实验室。参与者：24名健康年轻受试者：通过问卷调查，选择了12个早晨型和12个晚上型。每组包括6男6女。干预措施：无。测量和结果：根据首选的睡眠时间表记录8小时的多导睡眠图。睡眠阶段分析显示，早晨类型和晚上类型的睡眠结构没有差异。然而，早晨型的男性比晚上型的男性表现出更高的第一阶段睡眠比例和更低的睡眠效率。对6个频段的非快动眼睡眠脑电图进行频谱分析。早晨型与晚上型相比，在低sigma（12-14 Hz）有更多的频谱功率。女性和男性之间最显著的差异出现在高sigma（14-16 Hz）中，而在不同的生理时钟类型之间并不存在。慢波活动（1-5 Hz）的衰减速率在早晨类型中比晚上类型更快（P = 0.06）。这一比率几乎是相同的妇女和男子。结论：这些结果同意这一假设，即稳态睡眠调节不同的早晨类型和晚上类型，上午类型显示出更高的速度消散的睡眠压力在夜间的迹象。早晨-晚上似乎以一种性别特异的方式影响睡眠，男性更受他们的时钟类型的影响。
Study Objectives: To evaluate the influence of chronotype (morning types and evening types) on sleep stages and quantitative sleep electroencephalograms when constraints on the sleep schedule are minimal and when sex difference is taken into account.Design: A 48-hour session in the laboratory, including 2 nights of polysomnography, preceded by 7 days of ambulatory actigraphy.Setting: Chronobiology laboratory.Participants: Twenty-four healthy young subjects: 12 morning types and 12 evening types selected by questionnaire. Each group included 6 men and 6 women. Interventions: None.Measurements and Results: A polysomnography night of 8 hours in duration was recorded according to preferred sleep schedule. Sleep-stage analysis revealed that morning types and evening types did not differ in sleep architecture. However, morning-type men showed a higher percentage of stage I sleep and lower sleep efficiency than evening-type men. Electroencephalogram spectral analysis was conducted in non-rapid eye movement sleep for 6 frequency bands. Morning types had more spectral power in low sigma (12-14 Hz) compared with evening types. The most robust difference between women and men was found in high sigma (14-16 Hz) and was not present between chronotypes. The decay rate of slow-wave activity (1-5 Hz) tended to be faster in morning types compared with evening types (P =.06). This rate was almost identical for women and men.Conclusions: These results agree with the hypothesis that homeostatic sleep regulation differs between morning types and evening types, with morning types showing indications of a higher rate of dissipation of sleep pressure during the night. Morningness-eveningness seems to affect sleep in a sex-specific manner, with men being more affected by their chronotype.