Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design
Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design
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DOI：
10.1248/cpb.52.643
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发表时间：
2004-05-01
影响因子：
1.7
通讯作者：
Umeyama, H
中科院分区：
文献类型：
--
作者：
Takeda-Shitaka, M;Nojima, H;Umeyama, H
为了加快SARS药物的开发，我们利用自己的建模软件FAMS Ligand&Complex构建了SARS冠状病毒主要蛋白酶的同源模型，并在X射线结构解析之前发布。X-射线结构表明，我们的模型准确预测和基于结构的药物设计有用。
To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design.