Interactions of prefrontal cortex in relation to awareness in sensory learning
Interactions of prefrontal cortex in relation to awareness in sensory learning
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DOI：
10.1126/science.284.5419.1531
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发表时间：
1999-05-28
期刊：
影响因子：
56.9
通讯作者：
Lobaugh, NJ
中科院分区：
文献类型：
--
作者：
McIntosh, AR;Rajah, MN;Lobaugh, NJ
在联想学习范式中，人类受试者可以根据他们是否意识到一种音调预测了视觉事件而另一种则没有。只有有意识的受试者才会对音调产生不同的行为反应，左前额叶皮质的局部脑血流仅在有意识的受试者中表现出与学习相关的变化。左前额叶皮层与对侧前额叶皮层、感觉联合皮层和小脑的功能连接也发生了变化。这些结果表明，意识背后的大脑过程是通过大规模的神经认知系统的相互作用来介导的。
In an associative Learning paradigm, human subjects could be divided based on whether they were aware that one tone predicted a visual event and another did not. Only aware subjects acquired a differential behavioral response to the tones, Regional cerebral blood flow in left prefrontal cortex showed learning-related changes only in aware subjects. Left prefrontal cortex also showed changes in functional connectivity with contralateral prefrontal cortex, sensory association cortices, and cerebellum. Several of the interacting areas correlated with aware subjects' behavior, These results suggest cerebral processes underlying awareness are mediated through interactions of large-scale neurocognitive systems.