BINOL-Al catalysed asymmetric cyclization and amplification: preparation of optically active menthol analogs
BINOL-Al catalysed asymmetric cyclization and amplification: preparation of optically active menthol analogs
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DOI：
10.1039/c5ob00433k
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发表时间：
2015-01-01
影响因子：
3.2
通讯作者：
Sakamoto, Masami
中科院分区：
文献类型：
--
作者：
Itoh, Hisanori;Maeda, Hironori;Sakamoto, Masami
报道了手性联醇铝配合物催化的高选择性不对称关环烯反应。该反应从不饱和醛得到光学活性的6元环化醇，具有良好的非对映体和对映体选择性。通过改变催化剂中所用BINOL的ee来研究该反应的不对称放大。
We report a highly selective asymmetric ring-closing ene reaction catalysed by aluminum complexes with chiral BINOL. This reaction yields optically active 6-membered cyclized alcohols from unsaturated aldehydes, with good diastereo- and enantioselectivities. Asymmetric amplification of this reaction was investigated by varying the ee of the BINOL employed in the catalyst.