The physiological role of the brain GLP-1 system in stress.
The physiological role of the brain GLP-1 system in stress.
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DOI：
10.1080/23312025.2016.1229086
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发表时间：
2016-12-31
期刊：
影响因子：
--
通讯作者：
Trapp S
中科院分区：
文献类型：
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作者：
Holt MK;Trapp S
脑内的胰高血糖素样肽-1（GLP-1）是食物摄取的有效调节剂，并且大多数研究已经调查了中枢GLP-1的促胰岛素分泌作用。现在已经发现一系列大脑区域参与GLP-1介导的厌食症，包括一些传统上与食欲调节无关的区域。然而，食物摄入量的变化不仅可以指示能量需求的减少，而且还可以指示生物体在压力刺激后进食的动机的变化。事实上，众所周知，急性压力会减少食物摄入量。近年来，越来越多的研究集中在GLP-1在应激中的作用，并且发现中枢GLP-1系统响应于应激刺激而被激活。脑内GLP-1的来源，前胰高血糖素原（PPG）神经元，理想地位于脑干中以接收和传递应激信号，我们最近关于PPG神经元向脊髓的投射模式的数据表明与交感神经系统的潜在密切联系。我们在这里审查的作用，中央GLP-1在调节应激反应，并讨论了潜在的参与GLP-1的内源性来源在大脑中，PPG神经元。
Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been found to be activated in response to stressful stimuli. The source of GLP-1 within the brain, the preproglucagon (PPG) neurons, are ideally situated in the brainstem to receive and relay signals of stress and our recent data on the projection pattern of the PPG neurons to the spinal cord suggest a potential strong link with the sympathetic nervous system. We review here the role of central GLP-1 in the regulation of stress responses and discuss the potential involvement of the endogenous source of GLP-1 within the brain, the PPG neurons.